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微束放射生物学研究中的新挑战。

New challenges in radiobiology research with microbeams.

作者信息

Durante Marco, Friedl Anna A

出版信息

Radiat Environ Biophys. 2011 Aug;50(3):335-8. doi: 10.1007/s00411-011-0373-x. Epub 2011 Jun 12.

DOI:10.1007/s00411-011-0373-x
PMID:21667289
Abstract

There is a continuing interest in the use of microbeam systems designed to deliver ionizing radiation (both photons and particles) with a resolution of a few micrometers or less in biological targets. With more than 30 facilities currently in operation, several new research topics can be explored. In the 9th International Microbeam Workshop held in Darmstadt, Germany, in July 2010, several new ideas and results have been presented, indicating that microbeams will be increasingly important in radiobiology. Subnuclear targeting of single cells for DNA repair studies and microirradiation of 3D or small animal models are among the most promising new research perspectives.

摘要

人们一直对使用微束系统感兴趣,该系统旨在将电离辐射(光子和粒子)以几微米或更小的分辨率传递到生物靶标中。目前有30多个设施在运行,可以探索几个新的研究课题。在2010年7月于德国达姆施塔特举行的第9届国际微束研讨会上,提出了一些新的想法和成果,表明微束在放射生物学中将变得越来越重要。用于DNA修复研究的单细胞亚核靶向以及三维或小动物模型的微辐照是最有前景的新研究方向。

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