Greubel Christoph, Assmann Walter, Burgdorf Christian, Dollinger Günther, Du Guanghua, Hable Volker, Hapfelmeier Alexander, Hertenberger Ralf, Kneschaurek Peter, Michalski Dörte, Molls Michael, Reinhardt Sabine, Röper Barbara, Schell Stefan, Schmid Thomas E, Siebenwirth Christian, Wenzl Tatiana, Zlobinskaya Olga, Wilkens Jan J
Institut für Angewandte Physik und Messtechnik (LRT2), Universität der Bundeswehr München, 85579, Neubiberg, Germany.
Radiat Environ Biophys. 2011 Aug;50(3):339-44. doi: 10.1007/s00411-011-0365-x. Epub 2011 May 10.
A technical set-up for irradiation of subcutaneous tumours in mice with nanosecond-pulsed proton beams or continuous proton beams is described and was successfully used in a first experiment to explore future potential of laser-driven particle beams, which are pulsed due to the acceleration process, for radiation therapy. The chosen concept uses a microbeam approach. By focusing the beam to approximately 100 × 100 μm(2), the necessary fluence of 10(9) protons per cm(2) to deliver a dose of 20 Gy with one-nanosecond shot in the Bragg peak of 23 MeV protons is achieved. Electrical and mechanical beam scanning combines rapid dose delivery with large scan ranges. Aluminium sheets one millimetre in front of the target are used as beam energy degrader, necessary for adjusting the depth-dose profile. The required procedures for treatment planning and dose verification are presented. In a first experiment, 24 tumours in mice were successfully irradiated with 23 MeV protons and a single dose of 20 Gy in pulsed or continuous mode with dose differences between both modes of 10%. So far, no significant difference in tumour growth delay was observed.
本文描述了一种用于用纳秒脉冲质子束或连续质子束照射小鼠皮下肿瘤的技术装置，并在首次实验中成功用于探索激光驱动粒子束（由于加速过程而产生脉冲）在放射治疗中的未来潜力。所采用的概念是微束方法。通过将束斑聚焦到约100×100μm²，在23MeV质子的布拉格峰处，以一纳秒的脉冲实现每平方厘米10⁹个质子的必要注量，从而给予20Gy的剂量。电气和机械束扫描将快速剂量输送与大扫描范围相结合。在靶前一毫米处的铝板用作束能量降解器，这对于调整深度剂量分布是必要的。文中介绍了治疗计划和剂量验证所需的程序。在首次实验中，24只小鼠的肿瘤成功接受了23MeV质子的照射，以脉冲或连续模式给予单次剂量20Gy，两种模式之间的剂量差异为10%。到目前为止，未观察到肿瘤生长延迟有显著差异。
