从小鼠中枢神经系统有效清除小鼠肝炎病毒需要CD4+和CD8+ T细胞。
Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.
作者信息
Williamson J S, Stohlman S A
机构信息
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
出版信息
J Virol. 1990 Sep;64(9):4589-92. doi: 10.1128/JVI.64.9.4589-4592.1990.
Abstract
Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.
摘要
在用小鼠肝炎病毒JHM株感染后，从中枢神经系统清除病毒需要CD4+和CD8+ T细胞。抗病毒抗体的产生需要CD4+ T细胞的存在，但在病毒减少方面似乎起最小作用。所呈现的数据与以下假设一致，即JHM病毒的清除是由病毒特异性CD8+ T细胞介导的，而这些CD8+ T细胞似乎需要CD4+ T细胞的存在。
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