• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.从小鼠中枢神经系统有效清除小鼠肝炎病毒需要CD4+和CD8+ T细胞。
J Virol. 1990 Sep;64(9):4589-92. doi: 10.1128/JVI.64.9.4589-4592.1990.
2
T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system.T细胞介导的小鼠肝炎病毒JHM株从中枢神经系统的清除。
J Virol. 1989 Jul;63(7):3051-6. doi: 10.1128/JVI.63.7.3051-3056.1989.
3
T cell-mediated clearance of JHMV from the central nervous system.T细胞介导的从中枢神经系统清除JHMV。
Adv Exp Med Biol. 1990;276:557-63. doi: 10.1007/978-1-4684-5823-7_77.
4
Characterization of T cells expanded in vivo during primary mouse hepatitis virus infection in mice.小鼠原发性肝炎病毒感染期间体内扩增的T细胞的特征分析
J Vet Med Sci. 1996 May;58(5):431-7. doi: 10.1292/jvms.58.431.
5
CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.在嗜神经性小鼠肝炎病毒感染中枢神经系统后，CD4 T细胞有助于病毒控制和病理变化。
J Virol. 2008 Mar;82(5):2130-9. doi: 10.1128/JVI.01762-07. Epub 2007 Dec 19.
6
Mouse hepatitis virus 3-thymic cell interactions correlating with viral pathogenicity.与病毒致病性相关的小鼠肝炎病毒3型与胸腺细胞的相互作用。
J Immunol. 1991 May 1;146(9):3152-9.
7
Protective cellular retroviral immunity requires both CD4+ and CD8+ immune T cells.保护性细胞逆转录病毒免疫需要CD4+和CD8+免疫T细胞。
J Virol. 1991 Jan;65(1):220-4. doi: 10.1128/JVI.65.1.220-224.1991.
8
Responses of mice to murine coronavirus immunization.小鼠对鼠冠状病毒免疫的反应。
Arch Virol. 1992;125(1-4):39-52. doi: 10.1007/BF01309627.
9
Fine specificity and genetic restriction of T cell clones specific for mouse hepatitis virus, strain JHM.针对小鼠肝炎病毒JHM株的T细胞克隆的精细特异性和遗传限制性。
Adv Exp Med Biol. 1984;173:331-43. doi: 10.1007/978-1-4615-9373-7_34.
10
Generation of antiviral CD11ahigh T cells in CD4+ T cell-depleted mice and adult thymectomized mice after mouse hepatitis virus infection.
J Vet Med Sci. 1996 May;58(5):465-7. doi: 10.1292/jvms.58.465.

引用本文的文献

1
Application of Antimicrobial Peptide LL-37 as an Adjuvant for Middle East Respiratory Syndrome-Coronavirus Antigen Induces an Efficient Protective Immune Response Against Viral Infection After Intranasal Immunization.抗菌肽LL-37作为中东呼吸综合征冠状病毒抗原佐剂的应用在鼻内免疫后诱导针对病毒感染的有效保护性免疫反应。
Immune Netw. 2022 Sep 26;22(5):e41. doi: 10.4110/in.2022.22.e41. eCollection 2022 Oct.
2
Virus-Specific Regulatory T Cells Persist as Memory in a Neurotropic Coronavirus Infection.神经亲和性冠状病毒感染中，病毒特异性调节性 T 细胞作为记忆细胞持续存在。
J Immunol. 2022 Apr 15;208(8):1989-1997. doi: 10.4049/jimmunol.2100794. Epub 2022 Apr 1.
3
T cell responses to SARS-CoV-2 in humans and animals.人类和动物对 SARS-CoV-2 的 T 细胞反应。
J Microbiol. 2022 Mar;60(3):276-289. doi: 10.1007/s12275-022-1624-z. Epub 2022 Feb 14.
4
Intranasal immunization with a Middle East respiratory syndrome-coronavirus antigen conjugated to the M-cell targeting ligand Co4B enhances antigen-specific mucosal and systemic immunity and protects against infection.鼻腔免疫接种中东呼吸综合征冠状病毒抗原与 M 细胞靶向配体 Co4B 缀合可增强抗原特异性黏膜和全身免疫，并可预防感染。
Vaccine. 2022 Jan 31;40(5):714-725. doi: 10.1016/j.vaccine.2021.12.057. Epub 2021 Dec 30.
5
Evaluating the role of chemokines and chemokine receptors involved in coronavirus infection.评估趋化因子和趋化因子受体在冠状病毒感染中的作用。
Expert Rev Clin Immunol. 2022 Jan;18(1):57-66. doi: 10.1080/1744666X.2022.2017282. Epub 2022 Jan 3.
6
Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice.缺乏N7-甲基转移酶活性的减毒活冠状病毒疫苗可在小鼠体内诱导体液免疫和细胞免疫反应。
Emerg Microbes Infect. 2021 Dec;10(1):1626-1637. doi: 10.1080/22221751.2021.1964385.
7
Insights into coronavirus immunity taught by the murine coronavirus.鼠冠状病毒带来的关于冠状病毒免疫的新认识。
Eur J Immunol. 2021 May;51(5):1062-1070. doi: 10.1002/eji.202048984. Epub 2021 Mar 22.
8
Lessons for COVID-19 Immunity from Other Coronavirus Infections.其他冠状病毒感染带来的 COVID-19 免疫经验教训。
Immunity. 2020 Aug 18;53(2):248-263. doi: 10.1016/j.immuni.2020.07.005. Epub 2020 Jul 14.
9
SARS-CoV-2 will constantly sweep its tracks: a vaccine containing CpG motifs in 'lasso' for the multi-faced virus.SARS-CoV-2 将不断扫荡其踪迹：一种含有 CpG 基序的“套索”疫苗，针对多面病毒。
Inflamm Res. 2020 Sep;69(9):801-812. doi: 10.1007/s00011-020-01377-3. Epub 2020 Jul 12.
10
Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system.小胶质细胞影响宿主防御、疾病和修复在小鼠冠状病毒感染中枢神经系统后。
Glia. 2020 Nov;68(11):2345-2360. doi: 10.1002/glia.23844. Epub 2020 May 25.

本文引用的文献

1
Murine coronaviruses: isolation and characterization of two plaque morphology variants of the JHM neurotropic strain.鼠冠状病毒：JHM嗜神经毒株两种噬斑形态变异株的分离与鉴定
J Gen Virol. 1982 Dec;63(2):265-75. doi: 10.1099/0022-1317-63-2-265.
2
In vivo and in vitro models of demyelinating disease: endogenous factors influencing demyelinating disease caused by mouse hepatitis virus in rats and mice.脱髓鞘疾病的体内和体外模型：影响大鼠和小鼠由小鼠肝炎病毒引起的脱髓鞘疾病的内源性因素。
Infect Immun. 1982 Sep;37(3):1248-60. doi: 10.1128/iai.37.3.1248-1260.1982.
3
Selective localization of wild type and mutant mouse hepatitis virus (JHM strain) antigens in CNS tissue by fluorescence, light and electron microscopy.通过荧光、光学和电子显微镜对野生型和突变型小鼠肝炎病毒（JHM株）抗原在中枢神经系统组织中的选择性定位。
J Neuroimmunol. 1981 Mar;1(1):81-92. doi: 10.1016/0165-5728(81)90010-2.
4
Chronic central nervous system demyelination in mice after JHM virus infection.JHM病毒感染后小鼠的慢性中枢神经系统脱髓鞘
Neurology. 1981 Jan;31(1):38-44. doi: 10.1212/wnl.31.1.38.
5
Hybridoma antibodies to the murine coronavirus JHM: characterization of epitopes on the peplomer protein (E2).针对鼠冠状病毒JHM的杂交瘤抗体：纤突蛋白（E2）上抗原表位的特性分析
J Gen Virol. 1984 Nov;65 ( Pt 11):1931-42. doi: 10.1099/0022-1317-65-11-1931.
6
Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody.鼠肝炎病毒4型（JHM株）诱导的神经疾病在体内受到单克隆抗体的调节。
Virology. 1984 Jan 30;132(2):261-70. doi: 10.1016/0042-6822(84)90033-3.
7
Natural killer cell activity during mouse hepatitis virus infection: response in the absence of interferon.小鼠肝炎病毒感染期间的自然杀伤细胞活性：在无干扰素情况下的反应
Int J Cancer. 1983 Mar 15;31(3):309-14. doi: 10.1002/ijc.2910310310.
8
Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies.JHM病毒脑脊髓炎中的脱髓鞘机制。电子显微镜研究。
Acta Neuropathol. 1973 Mar 30;24(1):76-85. doi: 10.1007/BF00691421.
9
Pathogenesis of demyelination induced by a mouse hepatitis.小鼠肝炎诱导的脱髓鞘发病机制。
Arch Neurol. 1973 May;28(5):298-303. doi: 10.1001/archneur.1973.00490230034003.
10
Generation of large granular T lymphocytes in vivo during viral infection.病毒感染期间体内大颗粒T淋巴细胞的生成。
J Immunol. 1986 Mar 15;136(6):2280-6.

从小鼠中枢神经系统有效清除小鼠肝炎病毒需要CD4+和CD8+ T细胞。

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.

作者信息

Williamson J S, Stohlman S A

机构信息

Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.

出版信息

J Virol. 1990 Sep;64(9):4589-92. doi: 10.1128/JVI.64.9.4589-4592.1990.

DOI:10.1128/JVI.64.9.4589-4592.1990
PMID:2166833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC247935/
Abstract

Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.

摘要

在用小鼠肝炎病毒JHM株感染后，从中枢神经系统清除病毒需要CD4+和CD8+ T细胞。抗病毒抗体的产生需要CD4+ T细胞的存在，但在病毒减少方面似乎起最小作用。所呈现的数据与以下假设一致，即JHM病毒的清除是由病毒特异性CD8+ T细胞介导的，而这些CD8+ T细胞似乎需要CD4+ T细胞的存在。