Toth L A, January B
Department of Comparative Medicine, University of Tennessee, Memphis 38163.
Lab Anim Sci. 1990 Jul;40(4):384-7.
Significant physiological variations that could influence experimental outcomes have been described in laboratory animals following shipping. The objective of the present study was to monitor a variety of physiologic parameters in rabbits after shipping, and to evaluate the time necessary for stabilization of these variables in the new environment. Data indicate that rabbits develop anorexia, hyperglycemia, neutrophilia, lymphopenia and elevated plasma cortisol concentrations immediately after shipping. Most of these effects abate within 2 days after arrival, suggesting that a minimum stabilization period of 48 hours after shipping is advisable prior to use of rabbits in experimental paradigms.
运输后实验动物出现的可能影响实验结果的显著生理变化已有相关描述。本研究的目的是监测运输后家兔的各种生理参数，并评估这些变量在新环境中稳定所需的时间。数据表明，家兔在运输后立即出现厌食、高血糖、嗜中性粒细胞增多、淋巴细胞减少和血浆皮质醇浓度升高。这些影响大多在到达后2天内减弱，这表明在将家兔用于实验范式之前，运输后至少48小时的稳定期是可取的。
