Castelhano-Carlos M J, Baumans V
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Lab Anim. 2009 Oct;43(4):311-27. doi: 10.1258/la.2009.0080098. Epub 2009 Jun 8.
Human interaction and physical environmental factors are part of the stimuli presented to laboratory animals everyday, influencing their behaviour and physiology and contributing to their welfare. Certain environmental conditions and routine procedures in the animal facility might induce stress responses and when the animal is unable to maintain its homeostasis in the presence of a particular stressor, the animal's wellbeing is threatened. This review article summarizes several published studies on the impact of environmental factors such as light, noise, cage cleaning and in-house transport on welfare and stress of laboratory rats. The behaviour and physiological responses of laboratory rats to different environmental housing conditions and routine procedures are reviewed. Recommendations on the welfare of laboratory rats and refinements in experimental design are discussed and how these can influence and improve the quality of scientific data.
人类互动和物理环境因素是每天呈现给实验动物的刺激因素的一部分，影响它们的行为和生理，并对它们的福利产生影响。动物设施中的某些环境条件和常规程序可能会引发应激反应，当动物在特定应激源存在的情况下无法维持体内平衡时，动物的健康就会受到威胁。这篇综述文章总结了几项已发表的研究，这些研究探讨了光照、噪音、笼舍清洁和内部运输等环境因素对实验大鼠福利和应激的影响。本文还综述了实验大鼠对不同环境饲养条件和常规程序的行为和生理反应。讨论了关于实验大鼠福利的建议以及实验设计的改进，以及这些如何影响和提高科学数据的质量。
