Chauhan Bhushan, Gupta Manish, Chauhan Komal
Department of Ear, Nose and Throat, Gian Sagar Medical College and Hospital, Punjab, India.
Allergy Rhinol (Providence). 2016 Jan;7(2):74-81. doi: 10.2500/ar.2016.7.0163.
Antioxidants have a preventive or therapeutic role in oxygen free radical-mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis.
Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B (n = 31) received FF with antioxidants for 6 weeks. Nasal and ocular symptoms were evaluated weekly by using a four-point categoric scale. The efficacy of the study drug was assessed based on the mean change from baseline of the total daytime nasal symptom scores, total nighttime nasal symptom scores, and the composite symptom scores.
The combined therapy (FF with antioxidants) resulted in marked improvements (p ≤ 0.05) in the mean total daytime nasal symptom scores, total nighttime nasal symptom scores, and composite symptom scores of subjects compared with ones treated with intranasal steroid (FF) alone, which highlighted the therapeutic effect of antioxidants in allergic rhinitis.
Significant improvement in clinical outcome was observed in subjects who received antioxidants along with FF. However, because this was an open-label study, the results must be interpreted with caution, and further double-blind, placebo-controlled, dose-ranging trials supplemented with different antioxidants together with intranasal steroids are suggested.
抗氧化剂在氧自由基介导的细胞和组织损伤中具有预防或治疗作用。本研究旨在探讨抗氧化剂与鼻用类固醇糠酸氟替卡松（FF）对常年性变应性鼻炎患者临床结局的治疗效果。
将常年性变应性鼻炎患者（n = 61）随机分为两组，A组（n = 30）接受FF治疗，B组（n = 31）接受FF联合抗氧化剂治疗，为期6周。每周使用四分分类量表评估鼻和眼部症状。基于白天总鼻症状评分、夜间总鼻症状评分和综合症状评分相对于基线的平均变化来评估研究药物的疗效。
与单独使用鼻用类固醇（FF）治疗的受试者相比，联合治疗（FF联合抗氧化剂）使受试者的白天总鼻症状评分、夜间总鼻症状评分和综合症状评分均有显著改善（p≤0.05），这突出了抗氧化剂在变应性鼻炎中的治疗作用。
接受FF联合抗氧化剂治疗的受试者临床结局有显著改善。然而，由于本研究为开放标签研究，结果必须谨慎解读，建议进一步开展双盲、安慰剂对照、不同抗氧化剂与鼻用类固醇联合的剂量范围试验。
