黏质和非黏质铜绿假单胞菌生物膜中多黏菌素和亚胺培南的药代动力学/药效学。
Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms.
机构信息
Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Juliane Maries Vej 22, DK-2100 Copenhagen, Denmark.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4469-74. doi: 10.1128/AAC.00126-11. Epub 2011 Jun 13.
Abstract
The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.
摘要
黏附性铜绿假单胞菌生物膜中黏质型和非黏质型铜绿假单胞菌对抗粘菌素和亚胺培南活性的时程表明，与浮游菌相比，粘菌素和亚胺培南的动力学分别保留了浓度和时间依赖性杀菌作用，但需要更高剂量的抗生素和更长的给药时间才能清除生物膜。黏附性铜绿假单胞菌生物膜比非黏附性生物膜更难清除。
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