Guangdong Cardiovascular Institute, Southern Medical University, Guangdong, PR China.
J Surg Oncol. 2011 Nov 1;104(6):598-603. doi: 10.1002/jso.21992. Epub 2011 Jun 13.
The purpose of this study was to investigate the role of heat shock protein 60 (HSP60) in the clinical pathology of lung adenocarcinoma, and to explore whether the expression of HSP60 can act as an independent predictor for tumor relapse and prognosis after radical resection of lung adenocarcinoma.
Paraffin sections of lung adenocarcinoma tumor tissues were collected from 103 patients. Using immunohistochemistry, the expression levels of HSP60 in lung adenocarcinoma were detected. The correlations between HSP60 expression and clinicopathological parameters as well as prognosis were statistically analyzed.
Of the 103 specimens, 70 cases (68.0%) showed a strongly positive expression of HSP60, five cases (4.8%) showed a negative expression, and 28 cases (27.2%) showed a weakly positive expression. The level of HSP60 expression was significantly correlated with TNM stage of the tumor (P = 0.015), and Eastern Cooperative Oncology Group (ECOG) performance status (P = 0.027). Multivariate statistical analysis showed that patient age, pathological T stage, N stage, and HSP60 expression were independent prognostic influence on disease-free survival (P = 0.008, 0.011, 0.010, and <0.001, respectively).
HSP60 may be a good biomarker to be applied in clinic to predict the prognosis of patients with lung adenocarcinoma.
本研究旨在探讨热休克蛋白 60（HSP60）在肺腺癌临床病理学中的作用，并探讨 HSP60 的表达是否可以作为肺腺癌根治性切除术后肿瘤复发和预后的独立预测因子。
收集 103 例肺腺癌肿瘤组织的石蜡切片。采用免疫组织化学方法检测肺腺癌中 HSP60 的表达水平。统计分析 HSP60 表达与临床病理参数及预后的相关性。
103 例标本中，70 例（68.0%）HSP60 表达呈强阳性，5 例（4.8%）呈阴性，28 例（27.2%）呈弱阳性。HSP60 表达水平与肿瘤 TNM 分期（P=0.015）和东部肿瘤协作组（ECOG）体能状态（P=0.027）显著相关。多因素统计分析显示，患者年龄、病理 T 分期、N 分期和 HSP60 表达是无病生存的独立预后影响因素（P=0.008、0.011、0.010 和<0.001）。
HSP60 可能是一种很好的临床生物标志物，可用于预测肺腺癌患者的预后。
