Robertson Centre for Biostatistics, Boyd Orr Building, University of Glasgow, Glasgow, UK.
Eur J Epidemiol. 2012 Jan;27(1):53-61. doi: 10.1007/s10654-011-9639-5. Epub 2011 Dec 21.
The relationship between parental BMI and that of their adult offspring, when increased adiposity can become a clinical issue, is unknown. We investigated the intergenerational change in body mass index (BMI) distribution, and examined the sex-specific relationship between parental and adult offspring BMI. Intergenerational change in the distribution of adjusted BMI in 1,443 complete families (both parents and at least one offspring) with 2,286 offspring (1,263 daughters and 1,023 sons) from the west of Scotland, UK, was investigated using quantile regression. Familial correlations were estimated from linear mixed effects regression models. The distribution of BMI showed little intergenerational change in the normal range (<25 kg/m(2)), decreasing overweightness (25-<30 kg/m(2)) and increasing obesity (≥30 kg/m(2)). Median BMI was static across generations in males and decreased in females by 0.4 (95% CI: 0.0, 0.7) kg/m(2); the 95th percentile increased by 2.2 (1.1, 3.2) kg/m(2) in males and 2.7 (1.4, 3.9) kg/m(2) in females. Mothers' BMI was more strongly associated with daughters' BMI than was fathers' (correlation coefficient (95% CI): mothers 0.31 (0.27, 0.36), fathers 0.19 (0.14, 0.25); P = 0.001). Mothers' and fathers' BMI were equally correlated with sons' BMI (correlation coefficient: mothers 0.28 (0.22, 0.33), fathers 0.27 (0.22, 0.33). The increase in BMI between generations was concentrated at the upper end of the distribution. This, alongside the strong parent-offspring correlation, suggests that the increase in BMI is disproportionally greater among offspring of heavier parents. Familial influences on BMI among middle-aged women appear significantly stronger from mothers than fathers.
父母的体重指数(BMI)与成年子女的 BMI 之间的关系尚不清楚,尤其是当肥胖成为一个临床问题时。我们调查了世代间体质指数(BMI)分布的变化,并研究了父母 BMI 与成年子女 BMI 之间的性别特异性关系。利用分位数回归分析了来自英国苏格兰西部的 1443 个完整家庭(父母双方和至少一个子女)中 2286 名子女(1263 名女性和 1023 名男性)的调整 BMI 分布的世代间变化,其中包括线性混合效应回归模型中的家族相关性估计。在正常范围(<25kg/m(2))中,BMI 的分布几乎没有世代间变化,超重(25-<30kg/m(2))的情况减少,肥胖(≥30kg/m(2))的情况增加。男性的 BMI 中位数在各代之间保持不变,女性的 BMI 中位数降低了 0.4(95%CI:0.0,0.7)kg/m(2);男性的第 95 百分位数增加了 2.2(1.1,3.2)kg/m(2),女性增加了 2.7(1.4,3.9)kg/m(2)。母亲的 BMI 与女儿的 BMI 比父亲的 BMI 更密切相关(相关系数(95%CI):母亲为 0.31(0.27,0.36),父亲为 0.19(0.14,0.25);P=0.001)。母亲和父亲的 BMI 与儿子的 BMI 同样相关(相关系数:母亲为 0.28(0.22,0.33),父亲为 0.27(0.22,0.33)。两代人之间 BMI 的增加主要集中在分布的较高端。加上亲子间的强相关性,这表明肥胖的增加在体重较重的父母的子女中不成比例地更大。在中年女性中,BMI 的家族影响似乎明显大于来自母亲的影响,而小于来自父亲的影响。