Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, Australia.
J Clin Sleep Med. 2011 Jun 15;7(3):261-7. doi: 10.5664/JCSM.1066.
To study the acute effect of the new SensAwake CPAP modality (reducing pressure on awakenings) on wake after sleep onset (WASO) and other polysomnographic measures in patients with obstructive sleep apnea (OSA).
Randomized crossover trial comparing an automatic continuous positive airway pressure device (AutoCPAP) with and without SensAwake on sleep architecture. CPAP naive patients received each therapy for a single night in the laboratory with at least 1-week washout. Both patients' and technicians' subjective satisfaction was assessed. Pressure data measured and stored by the AutoCPAP device were also analyzed.
OSA was controlled adequately by both modes (SensAwake ON apnea hypopnea index ± SD, AHI = 5.3 ± 5.6/h vs. SensAwake OFF = 5.4 ± 5.8, p = 0.9) in the 42 patients who completed the protocol. Mean and 90% pressures were significantly lower with SensAwake (mean ON = 6.9 ± 1.9 vs. OFF = 7.7 ± 2.5 cm H(2)O, p < 0.05; 90% pressure ON = 9.6 ± 2.7 vs. OFF = 10.6 ± 2.7 cm H(2)O, p < 0.02). SensAwake did not improve WASO (ON = 74 ± 54 min vs. OFF = 78 ± 51 min, p = 0.6). There were no differences in other sleep architecture measures or patient satisfaction between the 2 modalities. AutoCPAP-measured AHI closely approximated PSG-derived (ROC AUC = 0.81 [95% CI 0.71-0.92], p = 0.0001).
SensAwake provides similar control of the AHI to the standard AutoCPAP mode but does so at lower mean and 90% pressures. However, no measure of sleep architecture was significantly improved by the SensAwake mode during this initial acute exposure. The internal AutoCPAP AHI detection and calculation was similar to PSG-derived AHI measures. Longer term studies are needed to evaluate any long-term influence of SensAwake on WASO.
研究新型 SensAwake CPAP 模式（在觉醒时降低压力）对睡眠后觉醒（WASO）和阻塞性睡眠呼吸暂停（OSA）患者其他多导睡眠图测量指标的急性影响。
比较自动持续气道正压通气装置（AutoCPAP）在 SensAwake 开启和关闭两种模式下对睡眠结构影响的随机交叉试验。CPAP 治疗初治患者，在实验室中每种治疗方式均接受 1 个单夜治疗，至少 1 周洗脱期。评估患者和技术人员的主观满意度。同时分析由 AutoCPAP 设备测量和存储的压力数据。
在完成方案的 42 例患者中，两种模式均能充分控制 OSA（SensAwake 开启时的平均呼吸暂停低通气指数±标准差，AHI = 5.3 ± 5.6/h 与 SensAwake 关闭时，AHI = 5.4 ± 5.8，p = 0.9）。SensAwake 时的平均压力和 90%压力显著降低（SensAwake 开启时的平均压力为 6.9 ± 1.9 比关闭时的 7.7 ± 2.5 cm H2O，p < 0.05；90%压力开启时为 9.6 ± 2.7 比关闭时的 10.6 ± 2.7 cm H2O，p < 0.02）。SensAwake 并不能改善 WASO（开启时为 74 ± 54 min，关闭时为 78 ± 51 min，p = 0.6）。两种模式之间的其他睡眠结构测量指标或患者满意度无差异。AutoCPAP 测量的 AHI 与 PSG 衍生的 AHI 非常接近（ROC AUC = 0.81[95%CI 0.71-0.92]，p = 0.0001）。
SensAwake 为提供与标准 AutoCPAP 模式相似的 AHI 控制，但以更低的平均压力和 90%压力实现。然而，在这种初始急性暴露期间，SensAwake 模式并未显著改善任何睡眠结构指标。AutoCPAP 内部的 AHI 检测和计算与 PSG 衍生的 AHI 测量值相似。需要进一步进行长期研究以评估 SensAwake 对 WASO 的长期影响。
