基于光纤光学参量振荡器的多模态相干反斯托克斯拉曼光谱成像
Multimodal coherent anti-Stokes Raman spectroscopic imaging with a fiber optical parametric oscillator.
作者信息
Zhai Yan-Hua, Goulart Christiane, Sharping Jay E, Wei Huifeng, Chen Su, Tong Weijun, Slipchenko Mikhail N, Zhang Delong, Cheng Ji-Xin
出版信息
Appl Phys Lett. 2011 May 9;98(19):191106. doi: 10.1063/1.3589356. Epub 2011 May 10.
Abstract
We report on multimodal coherent anti-Stokes Raman scattering (CARS) imaging with a source composed of a femtosecond fiber laser and a photonic crystal fiber (PCF)-based optical parametric oscillator (FOPO). By switching between two PCFs with different zero dispersion wavelengths, a tunable signal beam from the FOPO covering the range from 840 to 930 nm was produced. By combining the femtosecond fiber laser and the FOPO output, simultaneous CARS imaging of a myelin sheath and two-photon excitation fluorescence imaging of a labeled axons in rat spinal cord have been demonstrated at the speed of 20 μs per pixel.
摘要
我们报道了一种多模态相干反斯托克斯拉曼散射（CARS）成像技术，其光源由飞秒光纤激光器和基于光子晶体光纤（PCF）的光学参量振荡器（FOPO）组成。通过在具有不同零色散波长的两根光子晶体光纤之间切换，产生了来自FOPO的可调谐信号光束，其覆盖范围为840至930纳米。通过将飞秒光纤激光器和FOPO输出相结合，已证明在大鼠脊髓中能够以每像素20微秒的速度同时进行髓鞘的CARS成像和标记轴突的双光子激发荧光成像。
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