Porta M, Bareggi S R, Collice M, Assael B M, Selenati A, Calderini G, Rossanda M, Morselli P L
Eur Neurol. 1975;13(6):545-54. doi: 10.1159/000114710.
Ventricular concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5HIAA) were measured in 7 patients a few days after a severe traumatic brain injury. Both acid metabolites were elevated in respect to control patients values, however, the rise was more consistent for 5HIAA (258 +/- 86 ng/ml) with a 5HIAA/HVA ratio of 0.85 +/- 0.35. The data support previous hypothesis on the profound involvement of serotoninergic structures in the early stages of acute traumatic brain syndromes and on the role of 5HT in maintaining edema and vasospasm.
在7例重度颅脑外伤患者伤后数天测量其脑室中高香草酸（HVA）和5-羟吲哚乙酸（5HIAA）的浓度。与对照患者的值相比，两种酸性代谢产物均升高，然而，5HIAA（258±86 ng/ml）的升高更一致，5HIAA/HVA比值为0.85±0.35。这些数据支持了先前关于血清素能结构在急性创伤性脑综合征早期阶段的深度参与以及5-羟色胺在维持水肿和血管痉挛中的作用的假说。
