Department of Surgery, Devision of surgical critical care and trauma, Korea University Guro hospital.
Yonsei University College of Medicine, Seoul, Korea.
Medicine (Baltimore). 2021 Jan 22;100(3):e23561. doi: 10.1097/MD.0000000000023561.
Some studies reported the correlations between renal parenchymal stiffness measured by transient elastography or acoustic radiation force impulse (ARFI) and the extent of interstitial fibrosis. This study was prospectively designed to evaluate the correlation between clinical, histological findings and the kidney shear wave velocity (SWV, m/s) assessed by ARFI elastography to identify factors affecting the kidney SWV in normal patients.
Seventy-three adult living kidney transplantation donors were enrolled in our center between September 2010 and January 2013. Before transplantation, all donors were evaluated by ARFI elastography to identify the range of SWV in kidneys. Time-zero biopsies were performed on all graft kidneys before implantation.
Mean age of donors was 42.0 ± 11.3 years. The mean SWV and depth were 2.21 ± 0.58 m/s and 5.37 ± 1.06 cm. All histological findings showed mild degree of the Banff score, only grade I. In univariate analyses, the SWV was not associated with all histological parameters. Age (r = -0.274, P = .019) diastolic blood pressure (DBP, r = -0.255, P = .030) and depth for SWV measurement (r = -0.345, P = .003) were significantly correlated with the SWV. In multivariate linear regression analysis, age, gender, body mass index (BMI), and depth for SWV measurement were significantly correlated with the SWV (P = .003, .005, .002, and .004, respectively).
We demonstrated that all histological findings are not correlated with the SWV of donor kidney. Otherwise, factors influencing the kidney SWV assessed by ARFI elastography are age, gender, BMI, and depth for the SWV measurement in donors for kidney transplantation.
一些研究报道了通过瞬时弹性成像或声辐射力脉冲（ARFI）测量的肾实质硬度与间质纤维化程度之间的相关性。本研究旨在前瞻性评估 ARFI 弹性成像评估的临床和组织学发现与肾脏剪切波速度（SWV，m/s）之间的相关性，以确定影响正常患者肾脏 SWV 的因素。
2010 年 9 月至 2013 年 1 月期间，我们中心共纳入 73 名成人活体肾移植供者。在移植前，所有供者均通过 ARFI 弹性成像评估以确定肾脏 SWV 的范围。所有移植物肾脏在植入前均进行零时活检。
供者的平均年龄为 42.0±11.3 岁。SWV 和深度的平均值分别为 2.21±0.58m/s 和 5.37±1.06cm。所有组织学发现均显示轻度的 Banff 评分，仅为 I 级。在单变量分析中，SWV 与所有组织学参数均无关。年龄（r=-0.274，P=0.019）、舒张压（DBP，r=-0.255，P=0.030）和 SWV 测量深度（r=-0.345，P=0.003）与 SWV 显著相关。在多元线性回归分析中，年龄、性别、体重指数（BMI）和 SWV 测量深度与 SWV 显著相关（P=0.003、0.005、0.002 和 0.004）。
我们表明，所有组织学发现与供体肾脏的 SWV 均不相关。相反，影响 ARFI 弹性成像评估的肾脏 SWV 的因素是年龄、性别、BMI 和供体肾脏 SWV 测量深度。
