Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 900, Chicago, IL 60611, USA.
Med Clin North Am. 2011 Jul;95(4):793-817, viii. doi: 10.1016/j.mcna.2011.03.006.
Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones--ciprofloxacin, levofloxacin, and moxifloxacin.
临床医生因其良好的安全性和广泛的适应证而热衷于使用氟喹诺酮类药物。本文综述了氟喹诺酮类药物的药理学、药效学原则和氟喹诺酮类耐药机制，重点介绍了近年来革兰氏阴性菌和肺炎链球菌中氟喹诺酮类耐药的流行病学趋势。本文还讨论了氟喹诺酮类药物的重要安全性问题，并介绍了最常用的氟喹诺酮类药物——环丙沙星、左氧氟沙星和莫西沙星的适应证。
