Yanavitski Marat, Givertz Michael M
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Curr Heart Fail Rep. 2011 Sep;8(3):206-11. doi: 10.1007/s11897-011-0065-5.
Heart failure goes beyond mechanical dysfunction and involves an interplay of multiple pathophysiologic mechanisms, including inflammation, tissue remodeling, neurohormonal and endocrine signaling, and interactions with the renal and nervous systems. This article highlights some novel biomarkers that may aid in diagnosis, treatment, and prognosis of acute heart failure, specifically focusing on ST2, endoglin, galectin-3, cystatin C, neutrophil gelatinase-associated lipocalin, midregional pro-adrenomedullin, chromogranin A, adiponectin, resistin, and leptin and their emerging clinical roles.
心力衰竭不仅仅是机械功能障碍，还涉及多种病理生理机制的相互作用，包括炎症、组织重塑、神经激素和内分泌信号传导，以及与肾脏和神经系统的相互作用。本文重点介绍了一些可能有助于急性心力衰竭诊断、治疗和预后评估的新型生物标志物，特别关注ST2、内皮糖蛋白、半乳糖凝集素-3、胱抑素C、中性粒细胞明胶酶相关脂质运载蛋白、中段肾上腺髓质素原、嗜铬粒蛋白A、脂联素、抵抗素和瘦素及其新出现的临床作用。
