Nutrition Research Center, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Iran.
Rheumatol Int. 2012 Aug;32(8):2407-14. doi: 10.1007/s00296-011-1979-7. Epub 2011 Jun 17.
To evaluate preventive and therapeutic effects of soy protein on collagen-induced arthritis rats. Sprague-Dawley rats immunized with bovine type II collagen emulsified in adjuvant and treated with soy protein (7 g/kg), dexamethasone (1 mg/kg), and casein (in control groups) by daily gavages feedings for 30 days. Score of arthritis recorded every day for each paws of animal. Tumor necrosis factor-alpha, interleukin6, leptin, and adiponectin were measured in serums. Treatment with soy protein resulted in significant delay in time to onset of arthritis as well as significantly decreased arthritis incidence, clinical arthritis severity score, histopathological arthritis severity score, and in vivo cell-mediated immunity to collagen (P < 0.05). Administration of soy protein significantly suppressed the progression of collagen II-induced arthritis and inhibited the production of tumor necrosis factor-alpha, interleukin6, leptin, and adiponectin. Soy protein appeared to be a potent immunomodulatory inhibitor of collagen II-induced arthritis in rats. It could delay onset of RA and reduced cartilage erosion and synovitis inflammation. Therefore, it may be a useful protein in the prevention and treatment of rheumatoid arthritis patient.
为了评估大豆蛋白对胶原诱导性关节炎大鼠的预防和治疗作用。将牛Ⅱ型胶原乳化佐剂免疫的 Sprague-Dawley 大鼠用大豆蛋白（7 g/kg）、地塞米松（1 mg/kg）和酪蛋白（对照组）通过每日灌胃喂养 30 天进行治疗。每天记录动物每只爪子的关节炎评分。测量血清中的肿瘤坏死因子-α、白细胞介素 6、瘦素和脂联素。大豆蛋白治疗可显著延迟关节炎发病时间，并显著降低关节炎发生率、临床关节炎严重程度评分、组织病理学关节炎严重程度评分和对胶原的体内细胞介导免疫（P<0.05）。大豆蛋白的给药显著抑制了胶原 II 诱导性关节炎的进展，并抑制了肿瘤坏死因子-α、白细胞介素 6、瘦素和脂联素的产生。大豆蛋白似乎是一种有效的胶原 II 诱导性关节炎大鼠的免疫调节抑制剂。它可以延迟 RA 的发病，并减少软骨侵蚀和滑膜炎炎症。因此，它可能是预防和治疗类风湿关节炎患者的有用蛋白。
