State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Front Med. 2011 Mar;5(1):33-9. doi: 10.1007/s11684-011-0114-1. Epub 2011 Mar 17.
Adult stem cells hold great promise for wound healing and tissue regeneration. Mesenchymal stem cells (MSCs), for example, have been shown to play a role in tissue repair. Research has shown that endogenous bone marrow MSCs or exogenously delivered MSCs migrate to the sites of injury and participate in the repair process. The precise mechanisms underlying migration of MSCs into the injured tissue are still not fully understood, although multiple signaling pathways and molecules were reported, including both chemoattractive factors and endogenous electric fields at wounds. This review will briefly summarize the regulatory facors and signaling transduction pathways involved in migration of MSCs. A better understanding of the molecular mechanisms involved in the migration of MSCs will help us to develop new stem cell-based therapeutic strategies in regenerative medicine.
成体干细胞在创伤愈合和组织再生方面具有巨大的应用潜力。例如，间充质干细胞（MSCs）已被证明在组织修复中发挥作用。研究表明，内源性骨髓间充质干细胞或外源性间充质干细胞迁移到损伤部位，并参与修复过程。尽管已经报道了包括趋化因子和伤口处内源性电场在内的多种信号通路和分子，但 MSCs 迁移到受损组织的确切机制仍不完全清楚。本文将简要总结参与 MSCs 迁移的调节因子和信号转导通路。更好地理解 MSCs 迁移所涉及的分子机制将有助于我们在再生医学中开发基于干细胞的新治疗策略。
