State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Front Med. 2011 Mar;5(1):40-4. doi: 10.1007/s11684-011-0108-z. Epub 2011 Mar 17.
Adult stem cells are responsible for homeostasis and repair of many tissues. Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, which is recognized to have an important role in regulating tissue maintenance and repair. In wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, and participate in the repair process. Many regulatory factors are involved in the stem cell-based repair process, including stem cell niches and endogenous wound electric fields, which are present at wound tissues and proved to be important in guiding wound healing. Here we briefly review the role of stem cell niches and endogenous electric fields in tissue repair, and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.
成体干细胞负责许多组织的稳态和修复。内源性成体干细胞存在于器官的某些区域，称为干细胞龛，该区域被认为在调节组织维持和修复方面起着重要作用。在伤口愈合和组织修复过程中，干细胞被动员并募集到伤口部位，并参与修复过程。许多调节因子参与基于干细胞的修复过程，包括干细胞龛和内源性伤口电场，这些因子存在于伤口组织中，并被证明在指导伤口愈合中很重要。在这里，我们简要回顾了干细胞龛和内源性电场在组织修复中的作用，并假设内源性电场成为伤口部位干细胞龛的一部分。
