Wong Victor W, Levi Benjamin, Rajadas Jayakumar, Longaker Michael T, Gurtner Geoffrey C
Department of Surgery, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
Int J Biomater. 2012;2012:926059. doi: 10.1155/2012/926059. Epub 2012 Jun 3.
Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration.
基于干细胞的疗法为损伤和疾病后的皮肤再生提供了巨大潜力。在人类皮肤的所有层次中都已发现功能性干细胞单元，而赋予这种再生潜力的物理和化学微环境线索的总和被称为干细胞生态位。毛囊隆突、毛囊间表皮、真皮乳头和血管周围间隙中的干细胞已作为生态位驱动再生的模型系统得到深入研究。这些研究表明，用于皮肤工程的干细胞策略必须考虑这些生态位复杂的分子和生物学特征。成功重现这些微环境的创新生物材料系统将促进祖细胞介导的皮肤修复和再生。
