Mihalik J, Toth S, Hodorova I, Vecanova J, Rybarova S
Department of Anatomy, Medical Faculty, Safarikiensis University, Kosice, Slovakia.
Bratisl Lek Listy. 2011;112(5):244-8.
Localization of monoamine oxidases (MAO) in rat female gonads during preimplantation period of pregnancy was determined.
Pregnant females were killed on their first, third, and fifth days of pregnancy and animals were transcardially perfused with PBS and fixative solutions. Ovaries, oviducts and uteri were immediately removed and they served for the determination of MAO localization employing the method of enzymatic histochemistry.
MAO-A activity in ovary was visible in corpora lutea and in interstitial gland cells while MAO-B was detected predominantly in blood vessels. Both MAO enzymes were seen in the smooth muscle fibers of the ovarian hilum. The presence of MAO enzymes was however not detected in follicles at any stage of their development. In oviduct and uterus, both MAO enzymes were visible in similar places, namely in smooth muscle fibers, mast cells and blood vessels, with no MAO presence seen in the epithelium.
Potential physiological importance of MAO localization in different cells of female reproductive organs during early period of pregnancy is proposed (Fig. 6, Ref. 29).
确定妊娠植入前期大鼠雌性性腺中单胺氧化酶（MAO）的定位。
在妊娠第1天、第3天和第5天处死怀孕雌性大鼠，经心脏用磷酸盐缓冲液（PBS）和固定液灌注动物。立即取出卵巢、输卵管和子宫，采用酶组织化学方法用于MAO定位的测定。
卵巢中的MAO - A活性可见于黄体和间质腺细胞，而MAO - B主要在血管中检测到。两种MAO酶均见于卵巢门的平滑肌纤维。然而，在卵泡发育的任何阶段均未检测到MAO酶的存在。在输卵管和子宫中，两种MAO酶均可见于类似部位，即平滑肌纤维、肥大细胞和血管中，上皮中未见MAO存在。
提出了妊娠早期MAO在雌性生殖器官不同细胞中定位的潜在生理重要性（图6，参考文献29）。
