Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, E-46100 Burjassot (València), Spain.
J Org Chem. 2011 Aug 5;76(15):6286-94. doi: 10.1021/jo2010704. Epub 2011 Jul 7.
Chiral complexes of 1,1'-bi-2-naphthol-based ligands with zirconium tert-butoxide catalyze the Friedel-Crafts alkylation of pyrroles with α-ketoesters to afford tertiary alcohols in good yields and ee up to 98%. The reaction is also of application to 4,7-dihydroindole to give C2-alkylated indoles after oxidation with p-benzoquinone.
基于 1,1'-联萘酚的手性配合物与叔丁醇锆配合物作为催化剂，可以催化吡咯与α-酮酯的傅克烷基化反应，以良好的收率和高达 98%的对映选择性得到仲醇。该反应也适用于 4,7-二氢吲哚，用对苯醌氧化后可以得到 C2-烷基化的吲哚。
