Mayans M V, Calvet X, Bruix J, Bruguera M, Costa J, Estève J, Bosch F X, Bru C, Rodés J
Liver Unit, Hospital Clínic i Provincial de Barcelona, Spain.
Int J Cancer. 1990 Sep 15;46(3):378-81. doi: 10.1002/ijc.2910460307.
The influence of hepatitis B virus infection, alcohol consumption, tobacco smoking and use of oral contraceptives on the risk of hepatocellular carcinoma (HCC) was evaluated in a hospital-based case-control study in Catalonia, in the Mediterranean coastal area of north-eastern Spain. A total of 96 HCC cases (86.5% of them with associated liver cirrhosis) and 190 age- and sex-matched controls were studied. The odds ratio of HCC and 95% confidence interval among hepatitis B surface antigen (HBsAg) carriers was 4.9 (1.3-21.9). The OR was not significantly elevated in smokers, and a marginally significant increased risk was found among users of oral contraceptives based on 6 female cases. There was a significant dose-response relationship between alcohol consumption and risk of HCC (chi 2 for trend: 24.3, p less than 0.001). Although hepatitis B infection was strongly associated with HCC, alcohol abuse leading to cirrhosis appears to be one of the main causes of HCC in this region.
在西班牙东北部地中海沿岸地区的加泰罗尼亚开展的一项基于医院的病例对照研究中，评估了乙肝病毒感染、饮酒、吸烟及口服避孕药的使用对肝细胞癌（HCC）风险的影响。共研究了96例HCC病例（其中86.5%伴有肝硬化）以及190例年龄和性别匹配的对照。乙肝表面抗原（HBsAg）携带者中HCC的比值比及95%置信区间为4.9（1.3 - 21.9）。吸烟者的OR未显著升高，基于6例女性病例发现口服避孕药使用者的风险有小幅显著增加。饮酒与HCC风险之间存在显著的剂量反应关系（趋势检验卡方值：24.3，p < 0.001）。虽然乙肝感染与HCC密切相关，但导致肝硬化的酒精滥用似乎是该地区HCC的主要原因之一。
