Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, TREND Knowledge Consortium, Leiden, Netherlands.
Lancet Neurol. 2011 Jul;10(7):637-48. doi: 10.1016/S1474-4422(11)70106-5.
A complex regional pain syndrome (CRPS)--multiple system dysfunction, severe and often chronic pain, and disability--can be triggered by a minor injury, a fact that has fascinated scientists and perplexed clinicians for decades. However, substantial advances across several medical disciplines have recently improved our understanding of CRPS. Compelling evidence implicates biological pathways that underlie aberrant inflammation, vasomotor dysfunction, and maladaptive neuroplasticity in the clinical features of CRPS. Collectively, the evidence points to CRPS being a multifactorial disorder that is associated with an aberrant host response to tissue injury. Variation in susceptibility to perturbed regulation of any of the underlying biological pathways probably accounts for the clinical heterogeneity of CRPS.
复杂性区域疼痛综合征（CRPS）——多系统功能障碍、严重且常为慢性疼痛以及残疾——可能由轻微损伤引发，这一事实几十年来一直令科学家着迷、令临床医生困惑。然而，多个医学学科的重大进展最近提高了我们对 CRPS 的理解。有力的证据表明，在 CRPS 的临床特征中，存在导致异常炎症、血管运动功能障碍和适应性神经可塑性的生物学途径。总的来说，这些证据表明 CRPS 是一种多因素疾病，与宿主对组织损伤的异常反应有关。对任何潜在生物学途径的调节紊乱的易感性差异可能解释了 CRPS 的临床异质性。
