Departamento de Sanidad Animal, Faculty of Veterinary Sciences, Universidad Complutense de Madrid, Avenida Puerta de Hierro, s/n 28040 Madrid, Spain.
Res Vet Sci. 2012 Apr;92(2):169-79. doi: 10.1016/j.rvsc.2011.05.017. Epub 2011 Jun 17.
Mycobacterium avium subspecies paratuberculosis (M. a. paratuberculosis) is responsible for paratuberculosis or Johne's disease, a chronic inflammation of the gastrointestinal tract in different animal species. Some studies have also established a link between this microorganism and Crohn's disease in humans. Although, M. a. paratuberculosis is a difficult microorganism to cultivate in the laboratory (occasionally is non-cultivable), a proper molecular characterization of M. a. paratuberculosis is necessary to better understand the epidemiology of the disease, and design strategies to eradicate it. In the present review, we compile and discuss the recent progress attained in the diagnostic and characterization of this pathogen.
分支杆菌亚种副结核分枝杆菌（M. a. paratuberculosis）可引起副结核病或约氏病，这是一种不同动物物种的胃肠道慢性炎症。一些研究还在这种微生物与人类克罗恩病之间建立了联系。尽管分支杆菌亚种副结核分枝杆菌在实验室中很难培养（偶尔是不可培养的），但对其进行适当的分子特征分析对于更好地了解该疾病的流行病学以及设计消灭它的策略是必要的。在本综述中，我们汇编并讨论了在该病原体的诊断和特征分析方面所取得的最新进展。
