Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), Av. Madrid s/n, 18071 Granada, Spain.
Sci Total Environ. 2011 Aug 15;409(18):3281-7. doi: 10.1016/j.scitotenv.2011.05.037.
To investigate the association between prenatal exposure to organochlorine pesticides (OCPs) and thyroid-stimulating hormone (TSH) levels in male newborns.
Exposure to 17 OCPs was analyzed in 220 placentas from a male birth cohort in Southern Spain, and TSH was measured in the umbilical cord blood. OCP concentrations were quantified by gas chromatography and mass spectrometry. Multivariate regression analysis was conducted to examine the association between pesticide exposure and neonatal TSH levels, adjusting for confounders.
Newborn boys with higher exposure to endrin in placenta had higher odds of TSH cord blood levels ≥ 5 mU/L (80th percentile) (OR=2.05; 95% CI=1.01, 4.18; p=0.05), whereas higher prenatal exposure to endosulfan-sulfate was associated with lower odds of TSH ≥ 5 mU/L (OR=0.36; 95% CI=0.17, 0.77; p=0.008). A marginally significant negative association was found between TSH and hexachlorobenzene levels (β=-0.15; 95% CI=-0.31, 0.02; p=0.09), and exposure to p,p'-DDE showed a marginally-significant higher odds of TSH ≥ 5 mU/L (OR=1.32; 95% CI=0.95, 1.83; p=0.09). No association was found between TSH and the remaining pesticides.
Early exposure to certain environmental chemicals with endocrine-disruption activity may interfere with neonatal thyroid hormone status; however, the pattern of interference is not yet clearly elucidated.
研究产前接触有机氯农药 (OCPs) 与男新生儿促甲状腺激素 (TSH) 水平之间的关系。
在西班牙南部的一个男性出生队列中，对 220 个胎盘进行了 17 种 OCP 的暴露分析，并在脐血中测量了 TSH。OCP 浓度通过气相色谱和质谱法进行定量。采用多变量回归分析，调整混杂因素后，研究了农药暴露与新生儿 TSH 水平之间的关系。
胎盘内恩林丹暴露水平较高的男婴，其脐血 TSH 水平≥5mU/L（第 80 百分位）的可能性更高（OR=2.05；95%CI=1.01，4.18；p=0.05），而产前内硫磷硫酸盐暴露水平较高与 TSH≥5mU/L 的可能性降低相关（OR=0.36；95%CI=0.17，0.77；p=0.008）。TSH 与六氯苯水平之间存在边缘显著负相关（β=-0.15；95%CI=-0.31，0.02；p=0.09），而 p,p'-DDE 暴露则显示 TSH≥5mU/L 的可能性略有增加（OR=1.32；95%CI=0.95，1.83；p=0.09）。TSH 与其余农药之间未发现相关性。
早期接触具有内分泌干扰活性的某些环境化学物质可能会干扰新生儿甲状腺激素状态，但干扰模式尚不清楚。
