Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Adv Drug Deliv Rev. 2011 Aug 14;63(9):822-36. doi: 10.1016/j.addr.2011.03.017. Epub 2011 Jun 12.
Localized delivery of bioactive compounds from surfaces of biomedical devices affords significant therapeutic benefits, and often relies on the capability of surface coatings to provide spatial and temporal control over release rate. The layer-by-layer technique presents a unique means to construct surface coatings that can conform to a variety of biomaterial surfaces and serve as matrices enabling controlled delivery of bioactive molecules from surfaces. The versatility of layer-by-layer assembly enables construction of surface coatings of diverse chemistry and internal architecture with controlled release properties. This review focuses on recent developments in constructing such layered matrices using linear polymers, polymer nanoparticles and block copolymer micelles, including micelles with stimuli-responsive cores, as film building blocks and in controlling release rate of therapeutics from these matrices via degradation, application of pH, ionic strength, temperature, light, electric field and chemical or biological stimuli. Challenges and opportunities associated with fabrication of stratified multilayer films capable of multi-stage delivery of multiple drugs are also discussed.
从生物医学设备表面局部递送生物活性化合物可带来显著的治疗益处，通常依赖于表面涂层的能力来提供对释放速率的时空控制。层层技术提供了一种独特的方法来构建表面涂层，这些涂层可以适应各种生物材料表面，并作为基质，实现从表面控制生物活性分子的释放。层层组装的多功能性使得可以构建具有受控释放性能的不同化学性质和内部结构的表面涂层。本综述重点介绍了使用线性聚合物、聚合物纳米粒子和嵌段共聚物胶束构建此类层状基质的最新进展，包括具有刺激响应核的胶束，这些胶束可用作薄膜构建块，并通过降解、应用 pH 值、离子强度、温度、光、电场以及化学或生物刺激来控制治疗药物从这些基质中的释放速率。还讨论了制造能够进行多阶段递送多种药物的分层多层膜所面临的挑战和机遇。
