Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Mult Scler. 2011 Sep;17(9):1034-40. doi: 10.1177/1352458511409612. Epub 2011 Jun 17.
Cognitive impairment is a prevalent, disabling, and poorly managed consequence of multiple sclerosis (MS). This underscores the importance of considering alternative approaches, such as exercise training, for managing cognitive impairment in persons with MS. The consideration of exercise training is warranted based on evidence summarized in literature reviews and meta-analyses that (1) aerobic fitness, physical activity, and exercise training are associated with better cognitive function in older adults; and (2) exercise training has comparable effects on mobility and quality of life outcomes in older adults and persons with MS. To date, research examining aerobic fitness, physical activity, and exercise training effects on cognition in MS is nascent and mostly includes cross-sectional designs that provide preliminary evidence for a well-designed randomized controlled trial (RCT). We believe that a future RCT should adopt research methodologies and practices from gerontology when examining exercise training and cognition in MS. This will maximize the potential for successfully generating a body of knowledge on exercise training and cognition with the potential for impacting the lives of persons with MS.
认知障碍是多发性硬化症（MS）普遍存在、使人衰弱且管理不善的后果。这凸显了考虑替代方法的重要性，例如运动训练，以管理 MS 患者的认知障碍。考虑运动训练是有充分理由的，因为文献综述和荟萃分析总结的证据表明：（1）有氧健身、身体活动和运动训练与老年人更好的认知功能相关；（2）运动训练对老年人和 MS 患者的移动能力和生活质量结果具有可比的影响。迄今为止，研究有氧健身、身体活动和运动训练对 MS 认知影响的研究还处于起步阶段，主要包括横断面设计，为精心设计的随机对照试验（RCT）提供了初步证据。我们相信，未来的 RCT 在研究 MS 中的运动训练和认知时，应该采用老年医学的研究方法和实践。这将最大限度地提高利用运动训练和认知知识的潜力，从而有可能改善 MS 患者的生活。
