抗逆转录病毒治疗中断12天后，奈韦拉平血药浓度持续升高并出现药物超敏反应综合征。
Persistent high nevirapine blood level with DRESS syndrome 12 days after interruption of antiretroviral therapy.
作者信息
Breining Alice, Guihot Amelie, Warot Dominique, Canestri Ana, Peytavin Gilles, Bricaire Francois, Caumes Eric
机构信息
Pitie Salpetriere Hospital, Infectious Disease, 47-83 Boulevard de l Hôpital, Paris, 75013, France.
出版信息
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.07.2008.0475. Epub 2009 Mar 17.
Abstract
Nevirapine is an antiretroviral agent associated with drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Such a case in an immunocompetent woman recently treated with nevirapine for postexposure HIV prophylaxis is reported here. Despite a period of 12 days after interruption of treatment, a high blood level of nevirapine was still observed.
摘要
奈韦拉平是一种与药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征相关的抗逆转录病毒药物。本文报道了一名免疫功能正常的女性，近期因暴露后预防HIV而接受奈韦拉平治疗，出现了这样的病例。尽管在中断治疗12天后，仍观察到奈韦拉平的血药浓度较高。
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HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz.HLA-DRB1*01与奈韦拉平和依非韦伦引起的皮肤超敏反应相关。
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