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与雷特格韦相关的药物超敏反应伴嗜酸性粒细胞增多和系统症状(DRESS)综合征

DRESS syndrome associated with raltegravir.

作者信息

Zhang Kevin S, Modi Gunjan M, Hsu Sylvia

出版信息

Dermatol Online J. 2011 Aug 15;17(8):14.

PMID:21906494
Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity is a potentially life-threatening drug hypersensitivity syndrome most commonly associated with anticonvulsants, allopurinol, long-acting sulfonamides, dapsone, and minocycline. In the setting of HIV infection, the antiretroviral medicines abacavir, nevirapine, and efavirenz have all shown well-documented associations with DRESS syndrome. There has only been one case (in a poster presentation) of this syndrome in a patient who was taking raltegravir.

摘要

药物性嗜酸性粒细胞增多症及全身症状(DRESS)综合征或药物性超敏反应是一种潜在的危及生命的药物超敏综合征,最常与抗惊厥药、别嘌醇、长效磺胺类药物、氨苯砜和米诺环素相关。在HIV感染的情况下,抗逆转录病毒药物阿巴卡韦、奈韦拉平和依非韦伦均已被充分证明与DRESS综合征有关。在服用拉替拉韦的患者中,仅出现过一例该综合征(在一份海报展示中)。

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DRESS syndrome associated with raltegravir.与雷特格韦相关的药物超敏反应伴嗜酸性粒细胞增多和系统症状(DRESS)综合征
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引用本文的文献

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Drug reaction with eosinophilia and systemic symptoms related to antiretroviral treatment in human immunodeficiency virus patients.人类免疫缺陷病毒患者中与抗逆转录病毒治疗相关的伴有嗜酸性粒细胞增多和全身症状的药物反应。
Indian J Sex Transm Dis AIDS. 2017 Jul-Dec;38(2):163-170. doi: 10.4103/ijstd.IJSTD_70_17.
2
Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir.在使用拉替拉韦治疗HIV感染期间,HLA - B*53:01等位基因与药物超敏反应伴嗜酸性粒细胞增多和全身症状(DRESS)综合征的关联。
Clin Infect Dis. 2017 May 1;64(9):1198-1203. doi: 10.1093/cid/cix096.
3
Antiviral drug allergy.
抗病毒药物过敏。
Immunol Allergy Clin North Am. 2014 Aug;34(3):645-62, ix. doi: 10.1016/j.iac.2014.04.011.
4
Extensive pulmonary involvement with raltegravir-induced DRESS syndrome in a postpartum woman with HIV.一名产后感染艾滋病毒的妇女出现广泛肺部受累的拉替拉韦诱导的药物反应伴嗜酸性粒细胞增多和系统症状综合征。
BMJ Case Rep. 2014 May 5;2014:bcr2013201545. doi: 10.1136/bcr-2013-201545.