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与雷特格韦相关的药物超敏反应伴嗜酸性粒细胞增多和系统症状(DRESS)综合征

DRESS syndrome associated with raltegravir.

作者信息

Zhang Kevin S, Modi Gunjan M, Hsu Sylvia

出版信息

Dermatol Online J. 2011 Aug 15;17(8):14.

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity is a potentially life-threatening drug hypersensitivity syndrome most commonly associated with anticonvulsants, allopurinol, long-acting sulfonamides, dapsone, and minocycline. In the setting of HIV infection, the antiretroviral medicines abacavir, nevirapine, and efavirenz have all shown well-documented associations with DRESS syndrome. There has only been one case (in a poster presentation) of this syndrome in a patient who was taking raltegravir.

摘要

药物性嗜酸性粒细胞增多症及全身症状(DRESS)综合征或药物性超敏反应是一种潜在的危及生命的药物超敏综合征,最常与抗惊厥药、别嘌醇、长效磺胺类药物、氨苯砜和米诺环素相关。在HIV感染的情况下,抗逆转录病毒药物阿巴卡韦、奈韦拉平和依非韦伦均已被充分证明与DRESS综合征有关。在服用拉替拉韦的患者中,仅出现过一例该综合征(在一份海报展示中)。

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