Hök K
Depart. of Medical Microbial Ecology, Karolinska Institute, Stockholm, Sweden.
APMIS. 1990 Jul;98(7):659-64. doi: 10.1111/j.1699-0463.1990.tb04985.x.
Cryosections of organs and smears from membrana nicitians from cats suspected of having spontaneous infection with feline infectious peritonitis virus (FIPV), were investigated using an indirect immunofluorescence assay (IIFA) in order to detect the presence of feline corona virus (FCV). In 113 cats, from each of which six organs were screened, virus antigen was found most often in membrana nicitians and lung. Out of these animals an additional six organs from a group of 30 cats were screened. In these cats membrana nicitians, parotid gland, thymus and apex of caecum had the highest incidence of virus antigen (90%). The lowest incidence of virus antigen was found in the spleen (60%). There was a clear demonstration of a higher incidence of antigen present in more than half of the total number of screened organs per cat (P less than 0.0005). No statistical difference was observed between sexes when comparing the incidence of virus antigen in different organs. Virus antigen was present in less organs in cats with no lesions suggestive of FIP disease compared to cats with such lesions (P less than 0.001). A similar distribution of the incidence of FCV antigen in the investigated organs was observed in these two groups.
为检测猫冠状病毒（FCV）的存在，对疑似自发感染猫传染性腹膜炎病毒（FIPV）的猫的器官冰冻切片和瞬膜涂片进行了间接免疫荧光测定（IIFA）。在113只猫中，每只猫的六个器官均接受筛查，病毒抗原最常出现在瞬膜和肺中。在这些动物中，又对一组30只猫的另外六个器官进行了筛查。在这些猫中，瞬膜、腮腺、胸腺和盲肠顶端的病毒抗原发生率最高（90%）。脾脏中的病毒抗原发生率最低（60%）。明显显示，每只猫筛查的器官总数中，超过一半的器官中抗原发生率较高（P<0.0005）。比较不同器官中病毒抗原的发生率时，未观察到性别之间的统计学差异。与有FIP疾病病变提示的猫相比，无FIP疾病病变提示的猫的器官中病毒抗原出现的较少（P<0.001）。在这两组中，观察到FCV抗原发生率在被调查器官中的分布相似。
