Marini Francesca, Luzi Ettore, Brandi Maria Luisa
Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
J Thyroid Res. 2011;2011:407123. doi: 10.4061/2011/407123. Epub 2011 May 10.
MicroRNAs (miRNAs) are endogenous noncoding RNAs that negatively regulate gene expression by binding the 3' noncoding region of the messenger RNA targets inducing their cleavage or blocking the protein translation. They play important roles in multiple biological and metabolic processes, including developmental timing, signal transduction, and cell maintenance and differentiation. Their deregulation can predispose to diseases and cancer. miRNA expression has been demonstrated to be deregulated in many types of human tumors, including thyroid cancers, and could be responsible for tumor initiation and progression. In this paper we reviewed the available data on miRNA deregulation in different thyroid tumors and describe the putative role of miRNA in thyroid cancer development.
微小RNA（miRNA）是内源性非编码RNA，通过与信使RNA靶标的3'非编码区结合，诱导其切割或阻断蛋白质翻译，从而对基因表达进行负调控。它们在多种生物和代谢过程中发挥重要作用，包括发育时间、信号转导以及细胞维持和分化。其失调可能导致疾病和癌症。已证明miRNA表达在包括甲状腺癌在内的多种人类肿瘤中失调，并且可能是肿瘤发生和进展的原因。在本文中，我们综述了不同甲状腺肿瘤中miRNA失调的现有数据，并描述了miRNA在甲状腺癌发生中的假定作用。
