Pease Anthony, Miller Rex
College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Vet Radiol Ultrasound. 2011 Sep-Oct;52(5):492-7. doi: 10.1111/j.1740-8261.2011.01837.x. Epub 2011 Jun 20.
Diffusion tensor imaging (DTI) is a specialized magnetic resonance sequence to determine the direction of water molecule motion. Our hypothesis was that information derived from DTI will be significantly different in dogs with a spinal cord lesion compared with a normal dog. Eleven normal dogs and six dogs with a spinal cord lesions were imaged. DTI was performed along with standard T1- and T2-weighted sequences in transverse and sagittal planes. Fractional anisotrophy and apparent diffusion coefficient (ADC) were obtained using regions of interests centered on the cranial aspect, middle cranial, middle caudal, and caudal aspects of the spinal cord. In normal dogs, the DTI sequence was characterized by normal fiber tracking with no statistical difference between the four sections of spinal cord (P>0.05). In the dogs with a spinal cord lesion, there was a significant difference in fractional anisotropy between the two groups (P=0.0003) and the ADC analysis statistical significance (P=0.048) at the caudal most site. Based on these findings, DTI is a potentially useful method to evaluate the spinal cord in dogs.
扩散张量成像（DTI）是一种用于确定水分子运动方向的特殊磁共振序列。我们的假设是，与正常犬相比，患有脊髓损伤的犬从DTI获得的信息将有显著差异。对11只正常犬和6只患有脊髓损伤的犬进行了成像。在横断和矢状平面上，DTI与标准T1加权和T2加权序列一起进行。使用以脊髓颅侧、颅中、尾中及尾侧为中心的感兴趣区域获得分数各向异性和表观扩散系数（ADC）。在正常犬中，DTI序列的特征是正常的纤维追踪，脊髓的四个节段之间无统计学差异（P>0.05）。在患有脊髓损伤的犬中，两组之间的分数各向异性存在显著差异（P=0.0003），在最尾端部位的ADC分析具有统计学意义（P=0.048）。基于这些发现，DTI是一种评估犬脊髓的潜在有用方法。
