Notch：肠道的建筑师、景观设计师和守护者。
Notch: architect, landscaper, and guardian of the intestine.
机构信息
Department of Radiotherapy, Maastricht Radiation Oncology (MAASTRO)/GROW School for Developmental Biology and Oncology, Maastricht University Medical Center, Maastricht, The Netherlands.
出版信息
Gastroenterology. 2011 Aug;141(2):448-59. doi: 10.1053/j.gastro.2011.06.003. Epub 2011 Jun 12.
Abstract
In the past decade, enormous progress has been made in understanding the role of stem cells in physiologic tissue renewal and in pathologic processes such as cancer. These findings have shed light on the identity and biological properties of such cells and the intrinsic and extrinsic signals that balance stem cell self-renewal with differentiation. With its astonishing self-renewal capacity, the intestinal epithelium has provided a unique model to study stem cell biology, lineage specification, and cancer. Here we review the role of Notch signaling in physiologic cell renewal and differentiation in the intestine as well as during its malignant transformation.
摘要
在过去的十年中，人们在理解干细胞在生理组织更新和癌症等病理过程中的作用方面取得了巨大的进展。这些发现揭示了这些细胞的特性和生物学特性，以及平衡干细胞自我更新与分化的内在和外在信号。肠道上皮具有惊人的自我更新能力，为研究干细胞生物学、谱系特化和癌症提供了独特的模型。在这里，我们回顾了 Notch 信号在肠道的生理细胞更新和分化以及在其恶性转化过程中的作用。
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本文引用的文献
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Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.通过 Notch 信号通路直接调控 hes1 抑制 hath1 基因表达与溃疡性结肠炎中杯状细胞缺失有关。
Inflamm Bowel Dis. 2011 Nov;17(11):2251-60. doi: 10.1002/ibd.21611. Epub 2011 Jan 6.
2
Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.证据表明 Notch1 金属蛋白酶裂解位点在转化为激活构象时暴露增加。
Structure. 2011 Apr 13;19(4):546-54. doi: 10.1016/j.str.2011.01.016.
3
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.肠干细胞特征可识别结直肠肿瘤干细胞，并可预测疾病复发。
Cell Stem Cell. 2011 May 6;8(5):511-24. doi: 10.1016/j.stem.2011.02.020. Epub 2011 Mar 17.
4
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.独特的 ATOH1 和 Neurog3 需求将肠上皮中的微绒毛细胞定义为一种新的分泌细胞类型。
J Cell Biol. 2011 Mar 7;192(5):767-80. doi: 10.1083/jcb.201010127.
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Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer.Notch1 和 Notch2 对结直肠癌患者的预后有相反的影响。
Ann Oncol. 2011 Nov;22(11):2440-2447. doi: 10.1093/annonc/mdq776. Epub 2011 Mar 4.
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Cancer Cell. 2011 Jan 18;19(1):6-8. doi: 10.1016/j.ccr.2011.01.003.
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