Department of Radiotherapy, Maastricht Radiation Oncology (MAASTRO)/GROW School for Developmental Biology and Oncology, Maastricht University Medical Center, Maastricht, The Netherlands.
Gastroenterology. 2011 Aug;141(2):448-59. doi: 10.1053/j.gastro.2011.06.003. Epub 2011 Jun 12.
In the past decade, enormous progress has been made in understanding the role of stem cells in physiologic tissue renewal and in pathologic processes such as cancer. These findings have shed light on the identity and biological properties of such cells and the intrinsic and extrinsic signals that balance stem cell self-renewal with differentiation. With its astonishing self-renewal capacity, the intestinal epithelium has provided a unique model to study stem cell biology, lineage specification, and cancer. Here we review the role of Notch signaling in physiologic cell renewal and differentiation in the intestine as well as during its malignant transformation.
在过去的十年中，人们在理解干细胞在生理组织更新和癌症等病理过程中的作用方面取得了巨大的进展。这些发现揭示了这些细胞的特性和生物学特性，以及平衡干细胞自我更新与分化的内在和外在信号。肠道上皮具有惊人的自我更新能力，为研究干细胞生物学、谱系特化和癌症提供了独特的模型。在这里，我们回顾了 Notch 信号在肠道的生理细胞更新和分化以及在其恶性转化过程中的作用。
