路易体谱障碍中的叙事话语组织。
The organization of narrative discourse in Lewy body spectrum disorder.
机构信息
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA.
出版信息
Brain Lang. 2011 Oct;119(1):30-41. doi: 10.1016/j.bandl.2011.05.006.
Abstract
Narrative discourse is an essential component of day-to-day communication, but little is known about narrative in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB). We performed a detailed analysis of a semi-structured speech sample in 32 non-aphasic patients with LBSD, and we related their narrative impairments to gray matter (GM) atrophy using voxel-based morphometry. We found that patients with PDD and DLB have significant difficulty organizing their narrative speech. This was correlated with deficits on measures of executive functioning and speech fluency. Regression analyses associated this deficit with reduced cortical volume in inferior frontal and anterior cingulate regions. These findings are consistent with a model of narrative discourse that includes executive as well as language components and with an impairment of the organizational component of narrative discourse in patients with PDD and DLB.
摘要
叙事话语是日常交流的重要组成部分，但人们对路易体谱障碍（LBSD）中的叙事知之甚少，包括帕金森病（PD）、帕金森病伴痴呆（PDD）和路易体痴呆（DLB）。我们对 32 名非失语症 LBSD 患者的半结构化言语样本进行了详细分析，并使用基于体素的形态测量学将其叙事障碍与灰质（GM）萎缩相关联。我们发现 PDD 和 DLB 患者在组织叙事言语方面有明显的困难。这与执行功能和言语流畅性测量的缺陷相关。回归分析将这一缺陷与额下回和前扣带回区域皮质体积减少相关联。这些发现与包括执行功能和语言成分的叙事话语模型以及 PDD 和 DLB 患者叙事话语组织成分损伤的模型一致。
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