Cleland L G, Gibson R A, Neumann M, French J K
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Australia.
Prostaglandins Leukot Essent Fatty Acids. 1990 May;40(1):9-12. doi: 10.1016/0952-3278(90)90108-w.
Patients (n = 23) with definite or classical rheumatoid arthritis were given 18 g/day fish oil in gelatin capsules which provided 3.2 g/day EPA and 2.0 g/day DHA. The treatment period was 12 weeks followed by a 4 week washout period. Fish oil supplementation to the diet resulted in a substantial increase in the content of EPA and DHA in each of the plasma fractions examined (PL, TG, and CE). Little change was seen in the AA level of the TG and CE fractions but a modest decrease in AA was seen in PL. However the intake of fish oil caused a significant depression in the content of DGLA in the PL (p less than 0.005) and CE (p less than 0.01) fractions relative to baseline values. All changes had reverted to near baseline levels 4 weeks after dietary intervention. Since DGLA is the precursor of PGE1, which has been shown to be anti-inflammatory, our findings suggest that the anti-inflammatory effects of fish oil consumption could be mitigated by an associated reduction in DGLA.
23例确诊为典型类风湿性关节炎的患者，每天服用明胶胶囊装的鱼油18克，其中富含3.2克/天的二十碳五烯酸（EPA）和2.0克/天的二十二碳六烯酸（DHA）。治疗期为12周，随后是4周的洗脱期。在饮食中补充鱼油后，所检测的各血浆组分（磷脂、甘油三酯和胆固醇酯）中EPA和DHA的含量大幅增加。甘油三酯和胆固醇酯组分中的花生四烯酸（AA）水平变化不大，但磷脂中的AA略有下降。然而，相对于基线值，摄入鱼油导致磷脂（p<0.005）和胆固醇酯（p<0.01）组分中双高γ-亚麻酸（DGLA）的含量显著降低。饮食干预4周后，所有变化均恢复至接近基线水平。由于DGLA是前列腺素E1的前体，且已证明前列腺素E1具有抗炎作用，我们的研究结果表明，食用鱼油的抗炎作用可能会因DGLA的相应减少而减弱。
