Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan.
J Sex Med. 2011 Sep;8(9):2625-31. doi: 10.1111/j.1743-6109.2011.02362.x. Epub 2011 Jun 23.
Although there were marked racial differences in the clinical outcomes among Japanese men (JP), Caucasian men (CA), and Japanese American (JA) men with localized prostate cancer, the effect of race/ethnicity on sexual profiles remains unclear.
To determine differences of sexual profiles in JP, CA, and JA with localized prostate cancer.
A total of 412 JP, 352 CA, and 54 JA with clinically localized prostate cancer were enrolled in separate studies of health-related quality of life outcomes. We developed a collaborative study in each database.
Sexual function and bother were estimated before treatment with validated English and Japanese versions of the University of California in Los Angeles Prostate Cancer Index (UCLA PCI).
The CA reported the highest sexual function score of all. Even after controlling for age, prostate specific antigen, clinical T stage, Gleason score and comorbidity, the JP were more likely than the CA to report poor sexual desire, poor erection ability, poor overall ability to function sexually, and poor ability to attain orgasm. With regard to sexual bother, however, no differences were reported between CA and JP. The JA reported sexual function closely approximate that of the JP, and they were less likely than the CA to report erection ability and intercourse. The JA were more likely to feel distress from their sexual function than the CA. When the JA were divided into two groups according to the ethnicity of their partners, UCLA PCI sexual function scores were equivalent between JA-partnered men and men partnered with other races. On the other hand, JA-partnered men were significantly less likely to report sexual bother scores than men partnered with other races.
We found significant interethnic variations among CA, JP, and JA with prostate cancer in terms of their sexual profiles. Ethnicity and/or country appear to modify some of these variables.
尽管日本男性（JP）、白种人男性（CA）和日裔美国男性（JA）的局部前列腺癌患者的临床结局存在明显的种族差异，但种族/民族对性特征的影响仍不清楚。
确定患有局限性前列腺癌的 JP、CA 和 JA 的性特征差异。
共有 412 名 JP、352 名 CA 和 54 名 JA 局部前列腺癌患者分别参加了健康相关生活质量结果的独立研究。我们在每个数据库中都开展了合作研究。
在接受治疗前，使用加利福尼亚大学洛杉矶分校前列腺癌指数（UCLA PCI）的英文和日文版本评估性功能和困扰情况。
CA 的性功能评分最高。即使在控制年龄、前列腺特异性抗原、临床 T 分期、Gleason 评分和合并症后，JP 仍比 CA 更有可能报告性欲差、勃起能力差、整体性功能差和获得性高潮的能力差。然而，在性困扰方面，CA 和 JP 之间没有差异。JA 的性功能报告与 JP 相似，他们比 CA 更不可能报告勃起能力和性交。JA 比 CA 更有可能因性功能而感到痛苦。当 JA 根据其伴侣的种族分为两组时，与白人伴侣的 JA 和与其他种族伴侣的 JA 的 UCLA PCI 性功能评分相当。另一方面，与其他种族伴侣的 JA 相比，JA 报告的性困扰评分显著较低。
我们发现，在性特征方面，患有前列腺癌的 CA、JP 和 JA 之间存在显著的种族间差异。种族和/或国家似乎会改变其中的一些变量。
