Department of Ophthalmology, Erzurum Regional Education and Research Hospital, The Ministry of Health, Erzurum, Turkey.
Eye (Lond). 2011 Sep;25(9):1177-80. doi: 10.1038/eye.2011.145. Epub 2011 Jun 24.
Pseudoexfoliation (PEX) syndrome is characterized by the widespread deposition of abnormal extracellular fibrillary material on many ocular and extraocular tissues. We aimed to investigate the association between PEX syndrome and subclinical myocardial ischaemia, using tissue Doppler echocardiography.
Thirty-two patients with pseudoexfoliation syndrome (mean age: 66±9 years, 22 men) and 25 healthy individuals (mean age: 67±8 years, 13 men) were included in the study. Patients with overt coronary artery disease, congestive heart failure, valvular heart disease, cardiomyopathy, and left ventricular hypertrophy were excluded from the study. Tissue Doppler imaging was performed at the septal, lateral, anterior, and inferior mitral annuluses. Differences between the groups were evaluated by the unpaired t-test and the Mann-Whitney U-test, with a P-value of <0.05 considered significant.
Baseline clinical characteristics, two-dimensional, and Doppler echocardiography parameters were similar in the PEX and control groups. Peak systolic velocities at the septal, lateral, anterior, and inferior annuluses were significantly lower in patients with PEX syndrome (P<0.001, 0.01, 0.02, and 0.02, respectively). The early diastolic velocity at the septal annulus, and the ratio of early/late diastolic velocity at the lateral annulus were significantly lower in the study group (P=0.03).
PEX syndrome is a common disorder of extracellular matrix. Our data suggest that there may also be an association between PEX syndrome and subclinical myocardial ischaemia in patients who have no signs and symptoms of ischaemia. Thus, we think that ophthalmologists should consider informing their PEX syndrome patients' general practitioners about a possible cardiac risk.
假性剥脱（PEX）综合征的特征是广泛的异常细胞外纤维状物质在许多眼部和眼外组织中的沉积。我们旨在使用组织多普勒超声心动图研究 PEX 综合征与亚临床心肌缺血之间的关系。
32 名 PEX 综合征患者（平均年龄：66±9 岁，22 名男性）和 25 名健康对照者（平均年龄：67±8 岁，13 名男性）纳入研究。排除有明显冠状动脉疾病、充血性心力衰竭、瓣膜性心脏病、心肌病和左心室肥厚的患者。在间隔、侧壁、前壁和下侧壁二尖瓣环处进行组织多普勒成像。使用独立样本 t 检验和 Mann-Whitney U 检验评估组间差异，P 值<0.05 认为差异有统计学意义。
PEX 和对照组的基线临床特征、二维和多普勒超声心动图参数相似。PEX 综合征患者的间隔、侧壁、前壁和下侧壁瓣环的收缩期峰值速度明显降低（P<0.001、0.01、0.02 和 0.02）。间隔瓣环的早期舒张速度和侧壁瓣环的早期/晚期舒张速度比值在研究组中明显降低（P=0.03）。
PEX 综合征是一种常见的细胞外基质疾病。我们的数据表明，在没有缺血症状的 PEX 综合征患者中，PEX 综合征与亚临床心肌缺血之间也可能存在关联。因此，我们认为眼科医生应该考虑告知他们的 PEX 综合征患者的全科医生可能存在的心脏风险。
