French Dustin D, Margo Curtis E, Harman Lynn E
Department of Ophthalmology, Northwestern University Feinberg School of Medicine and VA Center of Excellence Chicago, IL, USA.
N Am J Med Sci. 2012 Oct;4(10):468-73. doi: 10.4103/1947-2714.101987.
Pseudoexfoliation is a systemic disorder characterized by the deposition of extracellular matrix material. The microfibrillar material that gives rise to the condition is visible clinically in the anterior segment of the eye, and is also found in other tissues, including blood vessels, skin, gallbladder, kidneys, lungs, and heart.
The present study aims to determine whether ocular pseudoexfoliation is associated with selected cardiovascular diseases.
A cross-section comparison study was conducted with the help of the Veterans Health Administration databases, using the International Classification of Diseases, Ninth revision, Clinical Modification for pseudoexfoliation of lens capsule and pseudoexfoliation glaucoma. Selected cardiovascular diseases and risk factors for cardiovascular disease were identified using the appropriate medical codes. Patients with primary open-angle glaucoma, chronic sinusitis, and benign prostatic hyperplasia served as the comparison groups. A logistic regression model was used to control for age, gender, race, and major cardiovascular risk factors.
There were 6,046 case patients with pseudoexfoliation; approximately half were diagnosed with pseudoexfoliation glaucoma. Various stages of ischemic heart disease, cardiomyopathy, and aortic aneurysm were significantly associated with ocular pseudoexfoliation, after controlling for age, gender, race, and major cardiovascular risk factors. Associations, in general, were less demonstrable relative to the primary open-angle glaucoma comparison group.
Associations of ocular pseudoexfoliation with cardiovascular diseases were generally fewer and less pronounced when compared to patients with primary open-angle glaucoma. These results add to the results of earlier studies, which suggest that open-angle glaucoma itself might be a risk factor for certain cardiovascular disorders.
假性剥脱是一种以细胞外基质物质沉积为特征的全身性疾病。导致这种情况的微纤维物质在临床上可见于眼前节，也存在于其他组织中，包括血管、皮肤、胆囊、肾脏、肺和心脏。
本研究旨在确定眼部假性剥脱是否与特定的心血管疾病相关。
借助退伍军人健康管理局数据库进行了一项横断面比较研究，使用国际疾病分类第九版临床修订本对晶状体囊假性剥脱和假性剥脱性青光眼进行编码。使用适当的医学编码确定选定的心血管疾病和心血管疾病风险因素。原发性开角型青光眼、慢性鼻窦炎和良性前列腺增生患者作为对照组。采用逻辑回归模型控制年龄、性别、种族和主要心血管风险因素。
有6046例假性剥脱病例患者；约一半被诊断为假性剥脱性青光眼。在控制年龄、性别、种族和主要心血管风险因素后，缺血性心脏病、心肌病和主动脉瘤的各个阶段与眼部假性剥脱显著相关。总体而言，与原发性开角型青光眼对照组相比，关联性不太明显。
与原发性开角型青光眼患者相比，眼部假性剥脱与心血管疾病的关联性通常较少且不太显著。这些结果补充了早期研究的结果，表明开角型青光眼本身可能是某些心血管疾病的一个风险因素。
