与L-色氨酸相关的疫情后嗜酸性粒细胞增多性肌痛综合征
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan.
作者信息
Allen Jeffrey A, Peterson Alicia, Sufit Robert, Hinchcliff Monique E, Mahoney J Matthew, Wood Tammara A, Miller Frederick W, Whitfield Michael L, Varga John
机构信息
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
出版信息
Arthritis Rheum. 2011 Nov;63(11):3633-9. doi: 10.1002/art.30514.
Abstract
Eosinophilia-myalgia syndrome (EMS) is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration. An epidemic of EMS in 1989 was linked to consumption of L-tryptophan that had originated from a single source. Following the ban by the Food and Drug Administration (FDA) on the sale of L-tryptophan, the incidence of EMS declined rapidly. Moreover, no new cases have been described since the FDA ban was lifted in 2005. We report the clinical, histopathologic, and immunogenetic features of a new case of L-tryptophan-associated EMS, along with evidence of activated transforming growth factor β and interleukin-4 signaling in the lesional skin.
摘要
嗜酸性粒细胞增多性肌痛综合征（EMS）的特征是肌痛和外周血嗜酸性粒细胞增多呈亚急性起病，随后出现慢性神经病变和皮肤硬结。1989年发生的一次EMS流行与食用来自单一来源的L-色氨酸有关。在食品药品监督管理局（FDA）禁止L-色氨酸销售后，EMS的发病率迅速下降。此外，自2005年FDA解除禁令以来，未再有新病例的报道。我们报告了一例新的L-色氨酸相关EMS病例的临床、组织病理学和免疫遗传学特征，以及病变皮肤中转化生长因子β和白细胞介素-4信号激活的证据。
相似文献
1
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan.与L-色氨酸相关的疫情后嗜酸性粒细胞增多性肌痛综合征
Arthritis Rheum. 2011 Nov;63(11):3633-9. doi: 10.1002/art.30514.
2
L-tryptophan and the eosinophilia-myalgia syndrome: current understanding of the etiology and pathogenesis.L-色氨酸与嗜酸性粒细胞增多性肌痛综合征：病因及发病机制的当前认识
J Invest Dermatol. 1993 Jan;100(1):97S-105S. doi: 10.1111/1523-1747.ep12356368.
3
Tryptophan toxicity: a pharmacoepidemiologic review of eosinophilia-myalgia syndrome.色氨酸毒性：嗜酸性粒细胞增多性肌痛综合征的药物流行病学综述
DICP. 1991 Nov;25(11):1259-62. doi: 10.1177/106002809102501116.
4
[A case of the eosinophilia-myalgia syndrome].[嗜酸性粒细胞增多性肌痛综合征一例]
Ryumachi. 1992 Aug;32(4):327-30; discussion 330-2.
5
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia.与慢性B淋巴细胞白血病可能相关的L-色氨酸相关嗜酸性粒细胞增多性肌痛综合征
Ann Hematol. 1998 Nov;77(5):235-8. doi: 10.1007/s002770050449.
6
Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome.昭和电工生产的色氨酸与流行性嗜酸性粒细胞增多性肌痛综合征。
J Rheumatol Suppl. 1996 Oct;46:81-8; discussion 89-91.
7
Eosinophilia myalgia syndrome.嗜酸性粒细胞增多性肌痛综合征
Semin Arthritis Rheum. 1997 Jun;26(6):788-93. doi: 10.1016/s0049-0172(97)80022-4.
8
Eosinophilia-myalgia syndrome among the non-L-tryptophan users and pre-epidemic cases.非L-色氨酸使用者及流行前病例中的嗜酸性粒细胞增多性肌痛综合征。
J Rheumatol. 1996 Oct;23(10):1784-7.
9
Tryptophan contaminants associated with eosinophilia-myalgia syndrome. The Eosinophilia-Myalgia Studies of Oregon, New York and New Mexico.与嗜酸性粒细胞增多性肌痛综合征相关的色氨酸污染物。俄勒冈州、纽约州和新墨西哥州的嗜酸性粒细胞增多性肌痛研究。
Am J Epidemiol. 1993 Aug 1;138(3):154-9. doi: 10.1093/oxfordjournals.aje.a116841.
10
Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique.关于L-色氨酸与嗜酸性粒细胞增多性肌痛综合征关联的流行病学研究：一篇评论
J Rheumatol Suppl. 1996 Oct;46:44-58; discussion 58-9.
引用本文的文献
1
Eosinophilic fasciitis.嗜酸性筋膜炎
Med Clin (Barc). 2025 Jun 20;165(4):107066. doi: 10.1016/j.medcli.2025.107066.
2
A Scoping Review of Eosinophilic Pneumonia and Antidepressants: An Association Not to Be Overlooked.嗜酸性粒细胞性肺炎与抗抑郁药的范围综述：一种不容忽视的关联。
Diseases. 2025 Jan 13;13(1):13. doi: 10.3390/diseases13010013.
3
Postnatal Development of the Circadian Rhythmicity of Human Pineal Melatonin Synthesis and Secretion (Systematic Review).人松果体褪黑素合成与分泌昼夜节律性的产后发育（系统评价）
Children (Basel). 2024 Sep 29;11(10):1197. doi: 10.3390/children11101197.
4
Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis.皮肤纤维化的临床、机制和治疗全景。
Sci Transl Med. 2024 Sep 25;16(766):eadn7871. doi: 10.1126/scitranslmed.adn7871.
5
The challenge of diagnosing and classifying eosinophilia and eosinophil disorders: A review.嗜酸性粒细胞增多症及嗜酸性粒细胞疾病的诊断与分类挑战：综述
Cent Eur J Immunol. 2024;49(1):60-69. doi: 10.5114/ceji.2024.136512. Epub 2024 Apr 19.
6
Safety evaluation of dried L-tryptophan fermentation product in Sprague-Dawley rats.Sprague-Dawley大鼠中L-色氨酸干燥发酵产物的安全性评价
Toxicol Rep. 2022 May 10;9:1099-1113. doi: 10.1016/j.toxrep.2022.05.005. eCollection 2022.
7
Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements.褪黑素会成为“下一个维生素 D”吗？：新兴科学、临床应用、安全性和膳食补充剂的综述。
Nutrients. 2022 Sep 22;14(19):3934. doi: 10.3390/nu14193934.
8
Analytical Chemistry of Impurities in Amino Acids Used as Nutrients: Recommendations for Regulatory Risk Management.用于营养物的氨基酸中杂质的分析化学：监管风险管理建议。
Nutrients. 2022 Jul 11;14(14):2838. doi: 10.3390/nu14142838.
9
Detection of impurities in dietary supplements containing L-tryptophan.检测含 L-色氨酸的膳食补充剂中的杂质。
Amino Acids. 2022 May;54(5):835-839. doi: 10.1007/s00726-022-03125-9. Epub 2022 Jan 18.
10
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer's Disease.药物治疗对阿尔茨海默病患者失眠的影响。
Drugs Aging. 2021 Nov;38(11):951-966. doi: 10.1007/s40266-021-00891-1. Epub 2021 Sep 27.
本文引用的文献
1
A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity.TGFbeta 反应基因特征与弥漫性硬皮病的一个亚组相关，该亚组疾病严重程度增加。
J Invest Dermatol. 2010 Mar;130(3):694-705. doi: 10.1038/jid.2009.318. Epub 2009 Oct 8.
2
Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms.L-色氨酸相关嗜酸性粒细胞增多性肌痛综合征及相关症状发生的免疫遗传风险和保护因素。
Arthritis Rheum. 2009 Oct 15;61(10):1305-11. doi: 10.1002/art.24460.
3
Molecular subsets in the gene expression signatures of scleroderma skin.硬皮病皮肤基因表达特征中的分子亚群。
PLoS One. 2008 Jul 16;3(7):e2696. doi: 10.1371/journal.pone.0002696.
4
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome.构建验证新诊断标准的金标准的严谨新方法，以嗜酸性粒细胞增多性肌痛综合征为例。
Arch Intern Med. 2001 Oct 22;161(19):2301-6. doi: 10.1001/archinte.161.19.2301.
5
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome.与嗜酸性粒细胞增多性肌痛综合征发病相关的L-色氨酸病例相关污染物的在线高效液相色谱-串联质谱结构表征
Toxicol Lett. 1998 Oct 15;99(2):139-50. doi: 10.1016/s0378-4274(98)00223-9.
6
Eosinophilia-myalgia syndrome among the non-L-tryptophan users and pre-epidemic cases.非L-色氨酸使用者及流行前病例中的嗜酸性粒细胞增多性肌痛综合征。
J Rheumatol. 1996 Oct;23(10):1784-7.
7
Eosinophilia-myalgia syndrome in patients ingesting a single source of L-tryptophan.摄入单一来源L-色氨酸的患者中的嗜酸性粒细胞增多性肌痛综合征。
J Rheumatol. 1993 Feb;20(2):273-8.
8
Pathological and immunological effects of ingesting L-tryptophan and 1,1'-ethylidenebis (L-tryptophan) in Lewis rats.在Lewis大鼠中摄入L-色氨酸和1,1'-亚乙基双（L-色氨酸）的病理和免疫效应。
J Clin Invest. 1993 Mar;91(3):804-11. doi: 10.1172/JCI116300.
9
Contaminants in L-tryptophan associated with eosinophilia myalgia syndrome.与嗜酸性粒细胞增多性肌痛综合征相关的L-色氨酸中的污染物。
Arch Environ Contam Toxicol. 1993 Jul;25(1):134-42. doi: 10.1007/BF00230724.
10
Eosinophilia-myalgia syndrome: mortality data from the US national surveillance system.嗜酸性粒细胞增多性肌痛综合征：来自美国国家监测系统的死亡率数据。
J Rheumatol. 1993 Oct;20(10):1711-7.
Zotero 插件