CsrA 和 TnaB 共同调节色氨酸酶活性，促进肠致病性大肠杆菌诱导秀丽隐杆线虫的细胞死亡。
CsrA and TnaB coregulate tryptophanase activity to promote exotoxin-induced killing of Caenorhabditis elegans by enteropathogenic Escherichia coli.
机构信息
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30329, USA.
出版信息
J Bacteriol. 2011 Sep;193(17):4516-22. doi: 10.1128/JB.05197-11. Epub 2011 Jun 24.
Abstract
Enteropathogenic Escherichia coli(EPEC) requires the tnaA-encoded enzyme tryptophanase and its substrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and the tryptophan permease TnaB coregulate tryptophanase activity, through mutually exclusive pathways, to stimulate toxin-mediated paralysis and killing of C. elegans.
摘要
肠致病性大肠杆菌（EPEC）需要 tnaA 编码的酶色氨酸酶及其底物色氨酸来合成扩散性外毒素，以杀死线虫秀丽隐杆线虫。在这里，我们证明 RNA 结合蛋白 CsrA 和色氨酸透酶 TnaB 通过相互排斥的途径共同调节色氨酸酶活性，以刺激毒素介导的秀丽隐杆线虫麻痹和杀伤。
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