Public Health Sciences, Karlstad University, Karlstad, Sweden.
Int J Environ Health Res. 2012;22(1):22-36. doi: 10.1080/09603123.2011.588322. Epub 2011 Jun 27.
Endotoxins are microbiological agents which ubiquitously exist in an indoor environment, and are believed to be causal agents for a number of diseases. This study investigated the indoor levels and determinants of endotoxins and their impact on asthma and allergy diseases among Swedish pre-school children. House dust samples from 390 homes of 198 case children with asthma and allergy and 202 healthy control children were collected in the Dampness Building and Health (DBH) study. House dust endotoxin levels in the child's bedroom and living rooms ranged from 479-188,000 EU/g dust and from 138-942,000 EU/g dust, respectively. Pet-keeping and agricultural activities were significantly associated with the higher endotoxin concentration levels in indoor dust. Endotoxins in theindoor environment did not associate to asthma and allergy diseases in the children. However, we found an association between endotoxins and the presence of disease symptoms in the sub-group of families without indoor pets.
内毒素是一种微生物制剂，普遍存在于室内环境中，被认为是许多疾病的致病因子。本研究调查了瑞典学龄前儿童室内内毒素水平及其决定因素，以及它们对哮喘和过敏疾病的影响。在潮湿建筑与健康（DBH）研究中，从 198 名哮喘和过敏的病例儿童和 202 名健康对照儿童的 390 个家庭中收集了室内灰尘样本。儿童卧室和客厅的室内灰尘内毒素水平分别为 479-188,000EU/g 灰尘和 138-942,000EU/g 灰尘。饲养宠物和农业活动与室内灰尘中更高的内毒素浓度水平显著相关。室内环境中的内毒素与儿童的哮喘和过敏疾病无关。然而，我们在没有室内宠物的家庭亚组中发现了内毒素与疾病症状存在之间的关联。
