Wu Francis Fu-Sheng, Siebers Robert, Chang Chin-Fu, Hsieh Shu-Wen, Wu Mei-Wen, Chen Chi-Ying, Pierse Nevil, Crane Julian
Department of Emergency Medicine, Changhua Christian Hospital, Changhua City, Taiwan.
J Asthma. 2009 Sep;46(7):745-9. doi: 10.1080/02770900903082597.
Indoor allergens and microbial bio-contaminants play a significant role in asthma symptoms. The aim of the study was to determine levels of house dust mite allergens, bacterial endotoxin, and fungal beta-glucan in homes of 120 asthmatic children in central Taiwan. Dust samples from 120 mattresses (67 double-sided) were analyzed for house dust mite allergens (Der p 1, Der f 1, and Blo t 5), endotoxin, and beta-glucan. Pillows (n = 118) were analyzed for house dust mite allergens only. Kitchen dust samples were analyzed for the cockroach allergen, Bla g 1. Blo t 5 was detected in 9.3% pillows and 82.2% mattresses, Der p 1 in 95.8% pillows and 93.2% mattresses, and Der f 1 in 82.2% pillows and 83.1% mattresses. Geometric mean levels (95% confidence interval) of endotoxin and beta-glucan in mattresses were 108.4 Eu/mg (81.4-144.2) and 25.2 microg/g (22.7-28.0), respectively. House dust mite allergens and endotoxin levels were significantly lower on the bamboo side of 67 mattresses, compared to the inner sprung mattress side. Geometric mean of kitchen Bla g 1 was 0.61 U/g (95% CI: 0.43-0.85). Given the presence of Der p 1, Der f 1 and Blo t 5 in central Taiwan, it is advised to measure allergens of all three house dust mite species to obtain a true index of allergen exposure. Bamboo sides of mattresses had significantly lower house dust mite allergens and endotoxin levels.
室内过敏原和微生物生物污染物在哮喘症状中起重要作用。本研究的目的是测定台湾中部120名哮喘儿童家中的屋尘螨过敏原、细菌内毒素和真菌β-葡聚糖水平。对120个床垫（67个双面）的灰尘样本进行了屋尘螨过敏原（Der p 1、Der f 1和Blo t 5）、内毒素和β-葡聚糖分析。仅对118个枕头进行了屋尘螨过敏原分析。对厨房灰尘样本进行了蟑螂过敏原Bla g 1分析。在9.3%的枕头和82.2%的床垫中检测到Blo t 5，在95.8%的枕头和93.2%的床垫中检测到Der p 1，在82.2%的枕头和83.1%的床垫中检测到Der f 1。床垫中内毒素和β-葡聚糖的几何平均水平（95%置信区间）分别为108.4 Eu/mg（81.4 - 144.2）和25.2 μg/g（22.7 - 28.0）。与弹簧床垫内侧相比，67个床垫竹席面的屋尘螨过敏原和内毒素水平显著较低。厨房Bla g 1的几何平均值为0.61 U/g（95%CI：0.43 - 0.85）。鉴于台湾中部存在Der p 1、Der f 1和Blo t 5，建议检测所有三种屋尘螨物种的过敏原，以获得过敏原暴露的真实指标。床垫的竹席面屋尘螨过敏原和内毒素水平显著较低。
