Leuzzi Giovanni, Vita Maria Letizia, Porziella Venanzio, Congedo Maria Teresa, Cesario Alfredo
Department of Thoracic Surgery, Catholic University of Sacred Heart, Rome, Italy.
J Cardiothorac Surg. 2011 Jun 27;6:87. doi: 10.1186/1749-8090-6-87.
Malignant pleural effusion (MPE) is a common clinical problem of concern for most of the pneumologists and thoracic surgeons. A general consensus regarding the use of talc poudrage in treatment of MPE exists, but only few studies analyzed in detail talc insufflation related pulmonary morbidity. In particular, ARDS talc-related is caused by physical and chemical effects of the small talc particles (50% particle size <15 μm) and its occurrence is independent from the underlying disease, the quantity of talc used or the technique of talc instillation. In our series we observed 3 cases only (0.75%) of talc-related lung injury. This data strongly confirm the low rate of talc-related lung injury after talc poudrage in treatment of MPE regardless the amount of talc insufflated.
恶性胸腔积液（MPE）是大多数胸科医生和胸外科医生关注的常见临床问题。对于滑石粉喷洒治疗MPE的应用已达成普遍共识，但仅有少数研究详细分析了滑石粉吹入相关的肺部发病率。特别是，与滑石粉相关的急性呼吸窘迫综合征（ARDS）是由小滑石颗粒（50%粒径<15μm）的物理和化学作用引起的，其发生与基础疾病、滑石粉用量或滑石粉注入技术无关。在我们的系列研究中，仅观察到3例（0.75%）与滑石粉相关的肺损伤。该数据有力地证实了滑石粉喷洒治疗MPE后滑石粉相关肺损伤的发生率较低，无论吹入的滑石粉量如何。
