Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Vasc Med. 2011 Aug;16(4):247-52. doi: 10.1177/1358863X11411360. Epub 2011 Jun 27.
Mechanisms underlying the role of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) in atherosclerotic development are not completely understood. We evaluated the relationship of Lp-PLA(2) with endothelial dysfunction, an early manifestation of atherosclerosis, in a cohort without known clinical cardiovascular disease. A total of 2809 participants in the Multi-Ethnic Study of Atherosclerosis underwent plasma Lp-PLA(2) mass and activity measurement and brachial artery flow-mediated vasodilation testing. In adjusted linear regression models, higher Lp-PLA(2) mass and activity levels were not associated with lower endothelial function (-0.04%, p = 0.51 and -0.09%, p = 0.10, respectively). Among individuals with subclinical atherosclerosis based on ankle-brachial index (ABI) or carotid intima-media thickness (IMT), Lp-PLA(2) mass and activity were not associated with lower endothelial function (-0.03%, p = 0.88 and -0.31%, p = 0.16 for ABI < 1.00; 0.01%, p = 0.94 and -0.15%, p = 0.20 for abnormal carotid IMT). In summary, Lp-PLA(2) is not associated with endothelial dysfunction, suggesting its role in atherosclerosis development is primarily related to other factors.
脂蛋白相关磷脂酶 A2（Lp-PLA2）在动脉粥样硬化发展中的作用机制尚不完全清楚。我们在一个没有已知临床心血管疾病的队列中评估了 Lp-PLA2 与内皮功能障碍（动脉粥样硬化的早期表现）之间的关系。动脉粥样硬化多民族研究中的 2809 名参与者接受了血浆 Lp-PLA2 质量和活性测量以及肱动脉血流介导的扩张试验。在调整后的线性回归模型中，较高的 Lp-PLA2 质量和活性水平与较低的内皮功能无关（分别为-0.04%，p=0.51 和-0.09%，p=0.10）。在基于踝臂指数（ABI）或颈动脉内膜中层厚度（IMT）的亚临床动脉粥样硬化个体中，Lp-PLA2 质量和活性与较低的内皮功能无关（ABI<1.00 时分别为-0.03%，p=0.88 和-0.31%，p=0.16；颈动脉 IMT 异常时分别为 0.01%，p=0.94 和-0.15%，p=0.20）。总之，Lp-PLA2 与内皮功能障碍无关，这表明其在动脉粥样硬化发展中的作用主要与其他因素有关。
