Katzenstein A L, Peiper S C
Department of Pathology, University of Alabama, Birmingham.
Mod Pathol. 1990 Jul;3(4):435-41.
Twenty-nine cases of lymphomatoid granulomatosis (LYG) were examined for Epstein-Barr virus (EBV) genomes by means of the polymerase chain reaction (PCR) technique on paraffin-embedded formalin-fixed tissue. EBV DNA sequences were identified in 21 cases (72.4%), while five examples of primary well differentiated lymphocytic lymphoma (WDLL) of lung and one metastatic large cell lymphoma to lung (lymph node origin) were negative. These findings support the hypothesis that LYG represents a unique form of lymphoma, and they suggest that its pathogenesis may be related to EBV infection.
采用聚合酶链反应（PCR）技术，对29例淋巴瘤样肉芽肿病（LYG）的石蜡包埋福尔马林固定组织进行了爱泼斯坦-巴尔病毒（EBV）基因组检测。21例（72.4%）检测到EBV DNA序列，而5例原发性肺高分化淋巴细胞淋巴瘤（WDLL）及1例肺转移性大细胞淋巴瘤（淋巴结来源）均为阴性。这些发现支持了LYG是一种独特淋巴瘤形式的假说，并提示其发病机制可能与EBV感染有关。
