慢性牙周炎患者分离的白色念珠菌的体外黏附。
In vitro adherence of Candida albicans isolated from patients with chronic periodontitis.
机构信息
Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, State University of São Paulo, São José dos Campos, Brazil.
出版信息
J Appl Oral Sci. 2011 Aug;19(4):384-7. doi: 10.1590/s1678-77572011005000014. Epub 2011 Jun 24.
UNLABELLED
Adherence is considered an extremely important virulence factor in yeast.
OBJECTIVE
The aim of this study was to analyze the adherence to epithelial cells of C. albicans isolated from patients with chronic periodontitis in comparison to healthy patients.
MATERIAL AND METHODS
Candida albicans cells isolated from individuals with chronic periodontitis (n=25) and healthy controls (n=25) were included in this study. Suspensions of C. albicans (10(6) cells/mL) and epithelial cells (10(5) cells/mL) were mixed and incubated at 37ºC for 1 h. The number of yeasts adhered to 25 epithelial cells was counted.
RESULTS
The number of C. albicans cells adhered to epithelial cells was statistically higher in the chronic periodontitis group than in the control group (Student's t-test, p=0.000).
CONCLUSION
The results of the present study suggest a higher Candida adherence of samples isolated from patients with chronic periodontitis.
未加标签
黏附性被认为是酵母中一种极其重要的毒力因素。
目的
本研究旨在分析比较慢性牙周炎患者和健康对照者分离的白念珠菌对上皮细胞的黏附性。
材料和方法
本研究纳入了 25 例慢性牙周炎患者和 25 例健康对照者分离的白念珠菌细胞。将白念珠菌（10(6)个细胞/ml）和上皮细胞（10(5)个细胞/ml）混悬液混合，在 37°C 下孵育 1 小时。计算黏附于 25 个上皮细胞的酵母数量。
结果
慢性牙周炎组黏附于上皮细胞的白念珠菌细胞数量明显高于对照组（Student's t 检验，p=0.000）。
结论
本研究结果提示，慢性牙周炎患者分离样本的白念珠菌黏附性更高。
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