Tsang C S, Samaranayake L P
Faculty of Dentistry, University of Hong Kong, The Prince Philip Dental Hospital, Hong Kong.
Br J Dermatol. 1999 Nov;141(5):852-8. doi: 10.1046/j.1365-2133.1999.03158.x.
Adherence to host surfaces is an essential prerequisite for colonization and infection. We compared the adherence of 15 oral isolates of Candida albicans harvested from human immunodeficiency virus (HIV)-infected individuals and 12 isolates from HIV-free individuals to buccal epithelial cells (BECs) from HIV-free individuals, and the adherence of a reference strain of C. albicans to BECs from HIV-infected as well as HIV-free individuals. C. albicans from HIV-infected individuals showed adherence values similar to those from HIV-free individuals. The clinical and laboratory parameters of the subjects from whom the Candida were isolated did not correlate with adherence. A reference strain of C. albicans (GDH 1957), however, adhered more readily to BECs from HIV-infected individuals than to cells from an HIV-free cohort. Several variables were found to be associated with the adherence of C. albicans to BECs from HIV-infected individuals: use of zidovudine, antibacterials and antiparasitics was associated with increased adhesion, while haemophilia, heterosexuality, bisexuality, increased age, decreased CD4 + count and use of folate were associated with a decreased candidal adhesion (all P < 0.05). Our data suggest that the quality of BECs including their receptivity to Candida may play an important part in increasing the oral yeast carriage in HIV infection.
黏附于宿主表面是定植和感染的必要前提。我们比较了从人类免疫缺陷病毒（HIV）感染个体中分离出的15株白色念珠菌口腔分离株以及从无HIV个体中分离出的12株分离株对无HIV个体颊黏膜上皮细胞（BEC）的黏附情况，以及白色念珠菌参考菌株对HIV感染个体和无HIV个体的BEC的黏附情况。来自HIV感染个体的白色念珠菌的黏附值与来自无HIV个体的相似。分离出念珠菌的受试者的临床和实验室参数与黏附情况无关。然而，白色念珠菌参考菌株（GDH 1957）对HIV感染个体的BEC的黏附比对无HIV队列个体的细胞更容易。发现几个变量与白色念珠菌对HIV感染个体的BEC的黏附有关：使用齐多夫定、抗菌药物和抗寄生虫药物与黏附增加有关，而血友病患者、异性恋、双性恋、年龄增加、CD4 + 计数降低和使用叶酸与念珠菌黏附降低有关（所有P < 0.05）。我们的数据表明，BEC的质量，包括它们对念珠菌的接受能力，可能在HIV感染中增加口腔酵母菌携带方面起重要作用。
