香桃木的次生代谢产物与生物活性
Secondary metabolites and bioactivities of Myrtus communis.
作者信息
Nassar Mahmoud I, Aboutabl El-Sayed A, Ahmed Rania F, El-Khrisy Ezzel-Din A, Ibrahim Khaled M, Sleem Amany A
机构信息
Department of Chemistry of Natural Compounds, Dokki, Cairo, Egypt.
出版信息
Pharmacognosy Res. 2010 Nov;2(6):325-9. doi: 10.4103/0974-8490.75449.
BACKGROUND
Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L.
METHODS
Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid.
RESULTS
Determination of the median lethal dose (LD(50)) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs.
CONCLUSION
Administration of extracts of M. communis leaves could be safe at the dose used in this study.
背景
香桃木属植物的特征在于含有酚酸、黄酮类化合物、单宁、挥发油和脂肪酸。它们可用于治疗多种疾病。因此，本研究调查了香桃木的药用效果。
方法
对香桃木叶片的挥发油、7%甲醇提取物和水提取物以及分离得到的化合物杨梅素3 - O - β - 吡喃葡萄糖苷、杨梅素3 - O - α - 鼠李吡喃糖苷和没食子酸进行生物活性研究。
结果
半数致死剂量（LD(50)）的测定表明，挥发油、乙醇提取物和水提取物实际上无毒且安全性高，因为未观察到致死情况。与对照组和参比药物相比，受试材料（挥发油、乙醇提取物和水提取物、杨梅素3 - O - β - 吡喃葡萄糖苷、杨梅素3 - O - α - 鼠李吡喃糖苷和没食子酸）显示出显著的降血糖、抗炎和镇痛作用。
结论
在本研究中使用的剂量下，香桃木叶片提取物的给药可能是安全的。
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