Dib Kaoutar, Cherrah Yahia, Rida Sana, Filali-Maltouf Abdelkarim, Ennibi OumKeltoum
Laboratory of Microbiology and Molecular Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco.
Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco.
Evid Based Complement Alternat Med. 2021 Oct 19;2021:8351332. doi: 10.1155/2021/8351332. eCollection 2021.
Clinical strains of and and two reference strains of were tested. The antibacterial activity of each studied plant extract was evaluated using agar diffusion and broth microdilution assays.
Both aqueous and methanolic extracts of exhibited high antibacterial activity against periodontal pathogens as compared to extracts. At concentrations of 2.5-0.32 mg/disc, inhibition zones of the methanolic extract of ranged from 19.66 ± 0.57 to 12.33 ± 0.57 mm. The methanolic extract of showed at concentrations of 5-0.63 mg/disc inhibition zones ranging from 15.66 ± 0.57 to 12 ± 0.00 mm. Its aqueous extract at concentration of 0.63 mg/disc showed no antimicrobial activity against the clinical and reference strain of . This study showed that methanolic and aqueous extracts of and have in vitro an antibacterial activity against periodontal pathogens. They could be use as ingredients of an oral antimicrobial agent for prevention or treatment of periodontal diseases. Further research on isolating the compounds from these plant extracts and their toxicity effect could be conducted.
测试了[具体细菌名称1]和[具体细菌名称2]的临床菌株以及[具体细菌名称3]的两种参考菌株。使用琼脂扩散法和肉汤微量稀释法评估每种研究植物提取物的抗菌活性。
与[具体植物名称2]提取物相比，[具体植物名称1]的水提取物和甲醇提取物对牙周病原体均表现出高抗菌活性。在浓度为2.5 - 0.32毫克/圆片时，[具体植物名称1]甲醇提取物的抑菌圈范围为19.66±0.57至12.33±0.57毫米。[具体植物名称2]的甲醇提取物在浓度为5 - 0.63毫克/圆片时，抑菌圈范围为15.66±0.57至12±0.00毫米。其水提取物在浓度为0.63毫克/圆片时，对[具体细菌名称3]的临床菌株和参考菌株未显示出抗菌活性。本研究表明，[具体植物名称1]和[具体植物名称2]的甲醇提取物和水提取物在体外对牙周病原体具有抗菌活性。它们可用作预防或治疗牙周疾病的口腔抗菌剂成分。可进一步开展从这些植物提取物中分离化合物及其毒性作用的研究。
