Deb Prabal, Manu V, Pradeep H, Bhatoe Harjinder Singh
Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
J Cytol. 2011 Apr;28(2):73-6. doi: 10.4103/0970-9371.80747.
Clear cell ependymoma (CCE) is an uncommon variant of ependymoma having a predilection for the supratentorial region. Histologically, it bears an uncanny resemblance to oligodendroglioma, central neurocytoma, hemangioblastoma and metastasis from clear cell carcinoma. Here, we report a rare case of clear cell ependymoma in a 45-year-old male, which histomorphologically resembled anaplastic oligodendroglioma on intraoperative smears, frozen section and routine light microscopy. Immunohistochemistry, however, helped to arrive at the correct diagnosis. Unlike other clear cell tumors of the brain parenchyma, CCE is known to follow an aggressive course and, hence, obtaining a correct diagnosis is imperative since it has a direct therapeutic and prognostic connotation.
透明细胞室管膜瘤（CCE）是室管膜瘤的一种罕见变体，好发于幕上区域。在组织学上，它与少突胶质细胞瘤、中枢神经细胞瘤、血管母细胞瘤以及透明细胞癌转移灶极为相似。在此，我们报告一例45岁男性的罕见透明细胞室管膜瘤病例，其在术中涂片、冰冻切片及常规光学显微镜下的组织形态学表现类似于间变性少突胶质细胞瘤。然而，免疫组化有助于做出正确诊断。与脑实质的其他透明细胞肿瘤不同，CCE已知病程呈侵袭性，因此，由于其具有直接的治疗和预后意义，获得正确诊断至关重要。
